Camila Salvador Sestario, Eduardo Inocente Jussiani, Avacir Casanova Andrello, Caio Cezar Nantes Martins, Aline Campos Zeffa, Viviane de Fátima Mestre, Solange de Paula Ramos, Maria José Sparça Salles
{"title":"产前暴露于牙周炎对Wistar大鼠幼鼠的产后影响","authors":"Camila Salvador Sestario, Eduardo Inocente Jussiani, Avacir Casanova Andrello, Caio Cezar Nantes Martins, Aline Campos Zeffa, Viviane de Fátima Mestre, Solange de Paula Ramos, Maria José Sparça Salles","doi":"10.1002/bdr2.2468","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Periodontitis during pregnancy is associated with preterm births and low birth weight. This study evaluated how experimental periodontitis induced in female rats impacts the physical development, motor skills, and dental and maxillary development of their pups.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>Pregnant Wistar rats were divided into the control group (C, <i>n</i> = 12) and the induced periodontal disease group (P, <i>n</i> = 12). Periodontitis was induced in the first maxillary molars 14 days before mating. Delivery occurred on the 21st day of gestation, and four offspring from each litter were evaluated (<i>n</i> = 48) for 30 days to verify physical and reflexological development. The first molars and alveolar bone were evaluated in 30-day-old animals using X-ray microtomography and histopathological analysis. Differences between groups were considered significant if <i>p</i> < 0.05.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The P group had a lower number of live offspring (9.4 ± 1.9 pups) than the C group (11.4 ± 2.1, <i>p</i> = 0.03). The P offspring group showed lower weight (F = 1.17; <i>p</i> < 0.0001) and length (F = 3.47; <i>p</i> < 0.0001), as well as delayed hair growth (<i>p</i> = 0.01) and eruption of incisors (<i>p</i> = 0.001). The P offspring presented a delay in the motor development of postural straightening (<i>p</i> = 0.01), adult gait (<i>p</i> = 0.01), and negative geotaxis (<i>p</i> = 0.01). No developmental anomalies were observed in the maxillary first molars; however, the P group showed a decreased number (<i>p</i> = 0.02) and increased distance (<i>p</i> = 0.007) between the maxillary bone trabeculae.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Periodontitis delayed physical and reflexological development and impaired maxillary bone quality in offspring.</p>\n </section>\n </div>","PeriodicalId":9121,"journal":{"name":"Birth Defects Research","volume":"117 4","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Postnatal Effects of Prenatal Exposure to Periodontitis in Wistar Rat Pups\",\"authors\":\"Camila Salvador Sestario, Eduardo Inocente Jussiani, Avacir Casanova Andrello, Caio Cezar Nantes Martins, Aline Campos Zeffa, Viviane de Fátima Mestre, Solange de Paula Ramos, Maria José Sparça Salles\",\"doi\":\"10.1002/bdr2.2468\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Periodontitis during pregnancy is associated with preterm births and low birth weight. This study evaluated how experimental periodontitis induced in female rats impacts the physical development, motor skills, and dental and maxillary development of their pups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Method</h3>\\n \\n <p>Pregnant Wistar rats were divided into the control group (C, <i>n</i> = 12) and the induced periodontal disease group (P, <i>n</i> = 12). Periodontitis was induced in the first maxillary molars 14 days before mating. Delivery occurred on the 21st day of gestation, and four offspring from each litter were evaluated (<i>n</i> = 48) for 30 days to verify physical and reflexological development. The first molars and alveolar bone were evaluated in 30-day-old animals using X-ray microtomography and histopathological analysis. Differences between groups were considered significant if <i>p</i> < 0.05.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The P group had a lower number of live offspring (9.4 ± 1.9 pups) than the C group (11.4 ± 2.1, <i>p</i> = 0.03). The P offspring group showed lower weight (F = 1.17; <i>p</i> < 0.0001) and length (F = 3.47; <i>p</i> < 0.0001), as well as delayed hair growth (<i>p</i> = 0.01) and eruption of incisors (<i>p</i> = 0.001). The P offspring presented a delay in the motor development of postural straightening (<i>p</i> = 0.01), adult gait (<i>p</i> = 0.01), and negative geotaxis (<i>p</i> = 0.01). No developmental anomalies were observed in the maxillary first molars; however, the P group showed a decreased number (<i>p</i> = 0.02) and increased distance (<i>p</i> = 0.007) between the maxillary bone trabeculae.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Periodontitis delayed physical and reflexological development and impaired maxillary bone quality in offspring.</p>\\n </section>\\n </div>\",\"PeriodicalId\":9121,\"journal\":{\"name\":\"Birth Defects Research\",\"volume\":\"117 4\",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-04-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Birth Defects Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2468\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Birth Defects Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2468","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
Postnatal Effects of Prenatal Exposure to Periodontitis in Wistar Rat Pups
Background
Periodontitis during pregnancy is associated with preterm births and low birth weight. This study evaluated how experimental periodontitis induced in female rats impacts the physical development, motor skills, and dental and maxillary development of their pups.
Method
Pregnant Wistar rats were divided into the control group (C, n = 12) and the induced periodontal disease group (P, n = 12). Periodontitis was induced in the first maxillary molars 14 days before mating. Delivery occurred on the 21st day of gestation, and four offspring from each litter were evaluated (n = 48) for 30 days to verify physical and reflexological development. The first molars and alveolar bone were evaluated in 30-day-old animals using X-ray microtomography and histopathological analysis. Differences between groups were considered significant if p < 0.05.
Results
The P group had a lower number of live offspring (9.4 ± 1.9 pups) than the C group (11.4 ± 2.1, p = 0.03). The P offspring group showed lower weight (F = 1.17; p < 0.0001) and length (F = 3.47; p < 0.0001), as well as delayed hair growth (p = 0.01) and eruption of incisors (p = 0.001). The P offspring presented a delay in the motor development of postural straightening (p = 0.01), adult gait (p = 0.01), and negative geotaxis (p = 0.01). No developmental anomalies were observed in the maxillary first molars; however, the P group showed a decreased number (p = 0.02) and increased distance (p = 0.007) between the maxillary bone trabeculae.
Conclusions
Periodontitis delayed physical and reflexological development and impaired maxillary bone quality in offspring.
期刊介绍：
The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks.
Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.
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