二钌(I)双环戊二烯配合物的体外细胞毒性调节

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2025-04-03 DOI:10.1002/aoc.70133

Benedetta Bertoncini, Kseniya Glinkina, Stefano Zacchini, Paul J. Dyson, Lorenzo Biancalana, Fabio Marchetti

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引用次数: 0

摘要

一系列通式[Ru2Cp2(CO)(L)(μ-CO){μ-CNMe (Cy)}]+ (L = NH3,[2]+)的二钌(I)氨基配合物；Py, [3]+, PPh3, [4]+；[5] + DMSO溶液;以三羰基前体[Ru2Cp2(CO)2(μ-CO){μ-CNMe (Cy)}]+为原料，制备了[Ru2Cp2(μ-H)(CO)2{μ-CNMe (Cy)}]， 7和[Ru2Cp2(μ-H)(CO)2}]。还研究了二钌(I)乙烯配合物[Ru2Cp2(CO)(μ-CO){μ-η1:η3-C (Ph)CHCNMe (Cy)}]+的反应性，为钢琴板凳Ru （II）环戊二烯配合物与含硫的五元金属环配体提供了途径。用红外光谱、多核磁共振光谱和x射线衍射（3例）对新化合物进行了表征。[2-6]CF3SO3在水中的溶解度、亲脂性以及在水/DMSO和细胞培养基中的形态受不同的单齿配体调控。随后，[1,3 - 6]+在体外对人卵巢癌细胞（A2780和A2780cis）和胚胎肾细胞（HEK293）进行了实验，显示出中等至强效的细胞毒性。

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Tuning In Vitro Cytotoxicity in Diruthenium(I) bis-Cyclopentadienyl Complexes

A series of diruthenium(I) aminocarbyne complexes of general formula [Ru₂Cp₂(CO)(L)(μ-CO){μ-CNMe (Cy)}]⁺ (L = NH₃, [2]⁺; Py, [3]⁺, PPh₃, [4]⁺; DMSO, [5]⁺; thiourea, [6]⁺) and [Ru₂Cp₂(μ-H)(CO)₂{μ-CNMe (Cy)}], 7, were prepared from the tricarbonyl precursor [Ru₂Cp₂(CO)₂(μ-CO){μ-CNMe (Cy)}]⁺. The reactivity of the diruthenium(I) vinyliminium complex [Ru₂Cp₂(CO)(μ-CO){μ-η¹:η³-C (Ph)CHCNMe (Cy)}]⁺, was also investigated, providing access to piano stool Ru (II) cyclopentadienyl complexes with a five-membered metallacyclic ligand containing sulfur. The new compounds were characterized by IR and multinuclear NMR spectroscopy and X-ray diffraction (in three cases). The solubility in water, lipophilicity, and the speciation of [2–6]CF₃SO₃ in water/DMSO and cell culture medium are regulated by different monodentate ligands. Subsequently, [1,3–6]⁺ were tested in vitro against human ovarian cancer cells (A2780 and A2780cis) and embryonic kidney cells (HEK293), demonstrating moderate to potent cytotoxicity.

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.