Bohdan Kozibroda, Jean-Marie Lehn, Andrey S. Klymchenko
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引用次数: 0
摘要
在他们的研究文章（e202419905）中，Andrey S. Klymchenko等人。引入一种动态人工神经递质多巴胺受体，该受体在脂质纳米反应器内将荧光染料的分子识别与动态亚胺键形成协同结合，触发其发射颜色变化。这种纳米探针能够以显著的选择性检测多巴胺，而不受竞争生物胺和生物液体（如血清、血浆、尿液和细胞裂解液）的干扰。
Frontispiz: Fluorescent Artificial Receptor for Dopamine based on Molecular Recognition-driven Dynamic Covalent Chemistry in a Lipid Nanoreactor
In their Research Article (e202419905), Andrey S. Klymchenko et al. introduce a dynamic artificial receptor for neurotransmitter dopamine that synergically combines molecular recognition with dynamic imine bond formation of a fluorescent dye inside a lipid nanoreactor, triggering its emission color change. This nanoprobe enables dopamine detection with remarkable selectivity without interference of competing biogenic amines and biological fluids, such as blood serum, plasma, urine and cell lysate.
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