带状疱疹患者血浆蛋白质组学分析以确定带状疱疹后神经痛风险的预测因子

IF 3.5 2区 医学 Q1 ANESTHESIOLOGY
Tianqi Zhang, Naikun Wang, Tong Zhu, Jin Xu, Mengjiao Tan, Ran Wang, Ying Han
{"title":"带状疱疹患者血浆蛋白质组学分析以确定带状疱疹后神经痛风险的预测因子","authors":"Tianqi Zhang,&nbsp;Naikun Wang,&nbsp;Tong Zhu,&nbsp;Jin Xu,&nbsp;Mengjiao Tan,&nbsp;Ran Wang,&nbsp;Ying Han","doi":"10.1002/ejp.70015","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Postherpetic neuralgia (PHN) is a common and severe complication of herpes zoster (HZ). However, the understanding of the pathological mechanism relevant in the earlier phase of PHN is limited. This study aimed to explore the association of plasma proteins with PHN risk and identify candidate proteins to predict PHN during the acute phase of HZ infection.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Liquid chromatography tandem mass spectrometry (LC–MS/MS)-based proteomic technology was used to profile characteristic proteins in 31 patients with HZ infection.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The levels of 318 plasma proteins were quantified in acute HZ infected patients by untargeted proteomics. Twenty-four plasma proteins were dysregulated in HZ infected patients developing PHN compared with recovered patients. Among these proteins, 16 plasma proteins may be correlated with PHN risk. TTR, NCAM1 and SH3BGRL3 were first proposed as candidate biomarkers for PHN. The baseline level of TTR increased, and NCAM1 and SH3BGRL3 decreased in the PHN group. They may affect the prognosis of HZ through extracellular exosome and complement activation (classical pathway). Besides, the baseline level of TTR may positively correlate with the pain severity of PHN.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Altered abundance of plasma proteins in HZ infected patients was associated with PHN risk. In this study, TTR, NCAM1 and SH3BGRL3 were identified as potential predictors of PHN in early HZ infected patients. These results contribute to revealing the pathological mechanism and potential therapeutic targets of PHN.</p>\n </section>\n \n <section>\n \n <h3> Significance Statement</h3>\n \n <p>This study first proved that protein expression in HZ infected patients with opposite outcomes is different, and proposed three potential biomarkers to predict PHN risk in the acute phase of HZ infection. Further research is needed to determine whether protein expression is related to the severity of pain.</p>\n </section>\n </div>","PeriodicalId":12021,"journal":{"name":"European Journal of Pain","volume":"29 5","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plasma Proteomic Analysis of Patients With Herpes Zoster to Identify Predictors of Postherpetic Neuralgia Risk\",\"authors\":\"Tianqi Zhang,&nbsp;Naikun Wang,&nbsp;Tong Zhu,&nbsp;Jin Xu,&nbsp;Mengjiao Tan,&nbsp;Ran Wang,&nbsp;Ying Han\",\"doi\":\"10.1002/ejp.70015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Postherpetic neuralgia (PHN) is a common and severe complication of herpes zoster (HZ). However, the understanding of the pathological mechanism relevant in the earlier phase of PHN is limited. This study aimed to explore the association of plasma proteins with PHN risk and identify candidate proteins to predict PHN during the acute phase of HZ infection.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Liquid chromatography tandem mass spectrometry (LC–MS/MS)-based proteomic technology was used to profile characteristic proteins in 31 patients with HZ infection.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The levels of 318 plasma proteins were quantified in acute HZ infected patients by untargeted proteomics. Twenty-four plasma proteins were dysregulated in HZ infected patients developing PHN compared with recovered patients. Among these proteins, 16 plasma proteins may be correlated with PHN risk. TTR, NCAM1 and SH3BGRL3 were first proposed as candidate biomarkers for PHN. The baseline level of TTR increased, and NCAM1 and SH3BGRL3 decreased in the PHN group. They may affect the prognosis of HZ through extracellular exosome and complement activation (classical pathway). Besides, the baseline level of TTR may positively correlate with the pain severity of PHN.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Altered abundance of plasma proteins in HZ infected patients was associated with PHN risk. In this study, TTR, NCAM1 and SH3BGRL3 were identified as potential predictors of PHN in early HZ infected patients. These results contribute to revealing the pathological mechanism and potential therapeutic targets of PHN.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Significance Statement</h3>\\n \\n <p>This study first proved that protein expression in HZ infected patients with opposite outcomes is different, and proposed three potential biomarkers to predict PHN risk in the acute phase of HZ infection. Further research is needed to determine whether protein expression is related to the severity of pain.</p>\\n </section>\\n </div>\",\"PeriodicalId\":12021,\"journal\":{\"name\":\"European Journal of Pain\",\"volume\":\"29 5\",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-04-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Pain\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ejp.70015\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ANESTHESIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pain","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ejp.70015","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景带状疱疹后带状神经痛(PHN)是带状疱疹(HZ)常见且严重的并发症。然而,对PHN早期相关病理机制的理解是有限的。本研究旨在探讨血浆蛋白与PHN风险的关系,并确定预测HZ感染急性期PHN的候选蛋白。方法采用液相色谱串联质谱(LC-MS /MS)技术对31例HZ感染患者的特征蛋白进行分析。结果采用非靶向蛋白质组学方法对急性HZ患者318种血浆蛋白进行了定量分析。与恢复的患者相比,发生PHN的HZ感染患者有24种血浆蛋白异常。在这些蛋白中,16种血浆蛋白可能与PHN风险相关。TTR、NCAM1和SH3BGRL3首次被提出作为PHN的候选生物标志物。PHN组TTR基线水平升高,NCAM1和SH3BGRL3降低。它们可能通过胞外外泌体和补体激活(经典途径)影响HZ的预后。此外,TTR基线水平可能与PHN疼痛严重程度呈正相关。结论HZ感染患者血浆蛋白丰度改变与PHN风险相关。在本研究中,TTR、NCAM1和SH3BGRL3被确定为早期HZ感染患者PHN的潜在预测因子。这些结果有助于揭示PHN的病理机制和潜在的治疗靶点。本研究首次证明了不同结局的HZ感染患者的蛋白表达是不同的,并提出了三种潜在的生物标志物来预测HZ感染急性期的PHN风险。需要进一步的研究来确定蛋白质表达是否与疼痛的严重程度有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma Proteomic Analysis of Patients With Herpes Zoster to Identify Predictors of Postherpetic Neuralgia Risk

Background

Postherpetic neuralgia (PHN) is a common and severe complication of herpes zoster (HZ). However, the understanding of the pathological mechanism relevant in the earlier phase of PHN is limited. This study aimed to explore the association of plasma proteins with PHN risk and identify candidate proteins to predict PHN during the acute phase of HZ infection.

Methods

Liquid chromatography tandem mass spectrometry (LC–MS/MS)-based proteomic technology was used to profile characteristic proteins in 31 patients with HZ infection.

Results

The levels of 318 plasma proteins were quantified in acute HZ infected patients by untargeted proteomics. Twenty-four plasma proteins were dysregulated in HZ infected patients developing PHN compared with recovered patients. Among these proteins, 16 plasma proteins may be correlated with PHN risk. TTR, NCAM1 and SH3BGRL3 were first proposed as candidate biomarkers for PHN. The baseline level of TTR increased, and NCAM1 and SH3BGRL3 decreased in the PHN group. They may affect the prognosis of HZ through extracellular exosome and complement activation (classical pathway). Besides, the baseline level of TTR may positively correlate with the pain severity of PHN.

Conclusion

Altered abundance of plasma proteins in HZ infected patients was associated with PHN risk. In this study, TTR, NCAM1 and SH3BGRL3 were identified as potential predictors of PHN in early HZ infected patients. These results contribute to revealing the pathological mechanism and potential therapeutic targets of PHN.

Significance Statement

This study first proved that protein expression in HZ infected patients with opposite outcomes is different, and proposed three potential biomarkers to predict PHN risk in the acute phase of HZ infection. Further research is needed to determine whether protein expression is related to the severity of pain.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
European Journal of Pain
European Journal of Pain 医学-临床神经学
CiteScore
7.50
自引率
5.60%
发文量
163
审稿时长
4-8 weeks
期刊介绍: European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信