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IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-04-02 DOI:10.1021/acs.nanolett.4c05008

Xuemei Zeng, Huilan Zhuang, Dazhuang Xu, Jinshan Liang, Lizhi Jiang, Sijie Shao, Panpan Xue, Gang Liu, Shuangqian Yan

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引用次数: 0

摘要

设计具有可控特性和明确机制的纳米酶，对于推动下一代肿瘤治疗功能生物材料的发展具有重大意义。在这里，我们开发了一种由金属有机框架（MOF）衍生的双金属硫化物纳米酶 FCS，可通过光热和催化联合疗法进行铁治疗。FCS 是通过将沸石咪唑框架-67（ZIF-67）硫化到硫化钴（Co3S4，CS）中，然后进行亚铁阳离子交换合成的，从而增强了近红外 II 光热转换和卓越的芬顿催化活性。理论计算将这些增强归因于铁的掺杂，它缩小了带隙，促进了到 H2O2 的电子转移，并降低了活性氧生成的能垒。FCS 可通过脂质过氧化有效诱导铁变态反应，同时支持 T2 加权磁共振成像。这项研究提出了一种将 MOF 转化为多功能肿瘤治疗剂的稳健策略，突出了金属离子掺杂在优化纳米酶性能方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Multifunctional Hollow Bimetallic Sulfide Nanozyme Enables Imaging-Guided Synergistic Ferrotherapy for Tumor Treatment

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Multifunctional Hollow Bimetallic Sulfide Nanozyme Enables Imaging-Guided Synergistic Ferrotherapy for Tumor Treatment

The design of nanozymes with controlled properties and well-defined mechanisms holds significant promise for advancing next-generation functional biomaterials for tumor theranostics. Here, we develop a metal–organic framework (MOF)-derived bimetallic sulfide nanozyme, FCS, for ferrotherapy via combined photothermal and catalytic therapies. FCS is synthesized by vulcanizing the zeolitic imidazolate framework-67 (ZIF-67) into cobalt sulfide (Co₃S₄, CS), followed by ferrous cation exchange, resulting in enhanced near-infrared II photothermal conversion and superior Fenton-like catalytic activity. Theoretical calculations attribute these enhancements to Fe doping, which narrows the band gap, promotes electron transfer to H₂O₂, and lowers the energy barrier for active oxygen species generation. FCS effectively induces ferroptosis through lipid peroxidation, while supporting T₂-weighted magnetic resonance imaging. This study presents a robust strategy for MOF transformation into multifunctional tumor theranostic agents, highlighting the role of metal ion doping in optimizing nanozyme performance.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.