O-GlcNAc转移酶是DNA甲基化和转座子沉默的关键调控因子

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-04-02 DOI:10.1038/s41594-025-01507-7

引用次数: 0

摘要

小鼠胚胎干细胞中O-GlcNAc转移酶的破坏会释放TET酶的活性，从而导致全基因组DNA甲基化减少和DNA羟甲基化增加。这导致转座因子的去抑制，以及一些附近基因的激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

O-GlcNAc transferase is a key regulator of DNA methylation and transposon silencing

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O-GlcNAc transferase is a key regulator of DNA methylation and transposon silencing

Disruption of the enzyme O-GlcNAc transferase in mouse embryonic stem cells unleashes the activity of TET enzymes, which cause genome-wide decreases in DNA methylation and increases in DNA hydroxymethylation. This leads to de-repression of transposable elements, as well as the activation of some nearby genes.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.