运动作为一种肾脏保护策略:减缓慢性肾脏病的进展和优化透析护理(博士学院奖)

IF 11.6 1区 医学 Q1 SPORT SCIENCES
Hugo de Luca Corrêa, Thiago dos Santos Rosa
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引用次数: 0

摘要

我的博士研究了阻力训练(RT)对慢性肾脏疾病(CKD)患者的生理、分子和临床特征的影响。这项工作包括6项研究,包括随机对照试验、流行病学分析、3-5和一项总括性综述,6探索肌肉质量和运动在不同疾病阶段CKD患者保持肾功能和改善健康结局中的作用。总共分析了来自1000多名患者的数据,涵盖了广泛的疾病严重程度和干预策略。CKD影响全球10%的人口,导致肾功能进行性下降,发病率增加和医疗费用高。肌肉损失在慢性肾病中很普遍,导致虚弱、炎症和心血管疾病,但运动在肾脏护理中仍未得到充分利用。RT已显示出缓解ckd相关肌肉萎缩的希望,但其可行性和长期影响尚不清楚。我的研究旨在通过评估RT如何影响肾功能,炎症和代谢健康来填补这一空白,目标是将运动作为CKD管理的关键治疗策略。这个博士学位包括一系列的实验和观察研究:
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exercise as a renal-protective strategy: slowing chronic kidney disease progression and optimising dialysis care (PhD Academy Award)
My PhD investigated the effects of resistance training (RT) on physiological, molecular and clinical profile in patients with chronic kidney disease (CKD). This work encompassed six studies, including randomised controlled trials,1 2 epidemiological analyses,3–5 and an umbrella review,6 exploring the role of muscle mass and exercise in preserving renal function and improving health outcomes in patients with CKD across different disease stages. In total, data from over 1000 patients were analysed, covering a wide spectrum of disease severity and intervention strategies. CKD affects >10% of the global population, leading to progressive renal function decline, increased morbidity and high healthcare costs. Muscle loss is prevalent in CKD, contributing to frailty, inflammation and cardiovascular disease, yet exercise remains underutilised in renal care. RT has shown promise in mitigating CKD-related muscle atrophy, but its feasibility and long-term impact remain unclear. My research aimed to fill this gap by evaluating how RT affects renal function, inflammation and metabolic health, with the goal of establishing exercise as a key therapeutic strategy in CKD management. This PhD included a series of experimental and observational studies:
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来源期刊
CiteScore
27.10
自引率
4.90%
发文量
217
审稿时长
3-8 weeks
期刊介绍: The British Journal of Sports Medicine (BJSM) is a dynamic platform that presents groundbreaking research, thought-provoking reviews, and meaningful discussions on sport and exercise medicine. Our focus encompasses various clinically-relevant aspects such as physiotherapy, physical therapy, and rehabilitation. With an aim to foster innovation, education, and knowledge translation, we strive to bridge the gap between research and practical implementation in the field. Our multi-media approach, including web, print, video, and audio resources, along with our active presence on social media, connects a global community of healthcare professionals dedicated to treating active individuals.
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