Luigi F Saccaro, Farnaz Delavari, Ben Meuleman, Nader Perroud, Dimitri Van De Ville, Camille Piguet
{"title":"海马体边缘-感觉运动拔河：动态功能连通性作为情绪失调患者后代的跨诊断易感性标志。","authors":"Luigi F Saccaro, Farnaz Delavari, Ben Meuleman, Nader Perroud, Dimitri Van De Ville, Camille Piguet","doi":"10.1016/j.bpsc.2025.03.007","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Emotion dysregulation (ED) is a key transdiagnostic symptom in several psychiatric disorders such as borderline personality disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. These disorders, defined herein as ED disorders (EDDs), share similarities in symptoms, comorbidity, and heritability, emphasizing the importance of a transdiagnostic approach to identify markers of vulnerability to EDDs in high-risk populations, such as the offspring of patients with an EDD (EDDoff). The hippocampus, central to ED, exhibits alterations across EDDs.</p><p><strong>Methods: </strong>We used a state-of-the-art approach (micro-coactivation patterns [μCAPs]) to study the transdiagnostic dynamic functional connectivity (dFC) of hippocampal subregions from resting-state functional magnetic resonance imaging of 201 participants (74 patients with an EDD, 57 EDDoff, 70 healthy control participants). μCAPs provide a data-driven differentiation within the seed region.</p><p><strong>Results: </strong>dFC between the sensorimotor network (SMN) and the hippocampal body was lower in patients with EDDs (false discovery rate [FDR]-corrected p = .0002) and in EDDoff (p<sub>FDR</sub> = .01) than in control participants, with EDDoff displaying an intermediate pattern between patients with EDDs and control participants. dFC between the limbic network (LN) and the hippocampal head was higher in patients with EDDs than in control participants (p<sub>FDR</sub> = .01) and EDDoff (p<sub>FDR</sub> = .01). A negative correlation was found between ED and the SMN (p<sub>FDR</sub> = .01), indicating increasing ED with decreasing SMN dFC with the hippocampus.</p><p><strong>Conclusions: </strong>Increased dFC between the hippocampal head and the LN, at the expense of the SMN, may represent a marker of disease in patients with EDDs. Lower dFC between the SMN and the hippocampal body may represent a marker of vulnerability to EDDs in EDDoff that is correlated with ED. Such a transdiagnostic construct represents a clinically relevant target for early interventions aimed at reducing vulnerability to EDDs in high-risk populations.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Limbic-Sensorimotor Tug of War for the Hippocampus: Dynamic Functional Connectivity as a Transdiagnostic Vulnerability Marker in Offspring of Patients With Emotion Dysregulation.\",\"authors\":\"Luigi F Saccaro, Farnaz Delavari, Ben Meuleman, Nader Perroud, Dimitri Van De Ville, Camille Piguet\",\"doi\":\"10.1016/j.bpsc.2025.03.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Emotion dysregulation (ED) is a key transdiagnostic symptom in several psychiatric disorders such as borderline personality disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. These disorders, defined herein as ED disorders (EDDs), share similarities in symptoms, comorbidity, and heritability, emphasizing the importance of a transdiagnostic approach to identify markers of vulnerability to EDDs in high-risk populations, such as the offspring of patients with an EDD (EDDoff). The hippocampus, central to ED, exhibits alterations across EDDs.</p><p><strong>Methods: </strong>We used a state-of-the-art approach (micro-coactivation patterns [μCAPs]) to study the transdiagnostic dynamic functional connectivity (dFC) of hippocampal subregions from resting-state functional magnetic resonance imaging of 201 participants (74 patients with an EDD, 57 EDDoff, 70 healthy control participants). μCAPs provide a data-driven differentiation within the seed region.</p><p><strong>Results: </strong>dFC between the sensorimotor network (SMN) and the hippocampal body was lower in patients with EDDs (false discovery rate [FDR]-corrected p = .0002) and in EDDoff (p<sub>FDR</sub> = .01) than in control participants, with EDDoff displaying an intermediate pattern between patients with EDDs and control participants. dFC between the limbic network (LN) and the hippocampal head was higher in patients with EDDs than in control participants (p<sub>FDR</sub> = .01) and EDDoff (p<sub>FDR</sub> = .01). A negative correlation was found between ED and the SMN (p<sub>FDR</sub> = .01), indicating increasing ED with decreasing SMN dFC with the hippocampus.</p><p><strong>Conclusions: </strong>Increased dFC between the hippocampal head and the LN, at the expense of the SMN, may represent a marker of disease in patients with EDDs. Lower dFC between the SMN and the hippocampal body may represent a marker of vulnerability to EDDs in EDDoff that is correlated with ED. Such a transdiagnostic construct represents a clinically relevant target for early interventions aimed at reducing vulnerability to EDDs in high-risk populations.</p>\",\"PeriodicalId\":93900,\"journal\":{\"name\":\"Biological psychiatry. 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Limbic-Sensorimotor Tug of War for the Hippocampus: Dynamic Functional Connectivity as a Transdiagnostic Vulnerability Marker in Offspring of Patients With Emotion Dysregulation.
Background: Emotion dysregulation (ED) is a key transdiagnostic symptom in several psychiatric disorders such as borderline personality disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. These disorders, defined herein as ED disorders (EDDs), share similarities in symptoms, comorbidity, and heritability, emphasizing the importance of a transdiagnostic approach to identify markers of vulnerability to EDDs in high-risk populations, such as the offspring of patients with an EDD (EDDoff). The hippocampus, central to ED, exhibits alterations across EDDs.
Methods: We used a state-of-the-art approach (micro-coactivation patterns [μCAPs]) to study the transdiagnostic dynamic functional connectivity (dFC) of hippocampal subregions from resting-state functional magnetic resonance imaging of 201 participants (74 patients with an EDD, 57 EDDoff, 70 healthy control participants). μCAPs provide a data-driven differentiation within the seed region.
Results: dFC between the sensorimotor network (SMN) and the hippocampal body was lower in patients with EDDs (false discovery rate [FDR]-corrected p = .0002) and in EDDoff (pFDR = .01) than in control participants, with EDDoff displaying an intermediate pattern between patients with EDDs and control participants. dFC between the limbic network (LN) and the hippocampal head was higher in patients with EDDs than in control participants (pFDR = .01) and EDDoff (pFDR = .01). A negative correlation was found between ED and the SMN (pFDR = .01), indicating increasing ED with decreasing SMN dFC with the hippocampus.
Conclusions: Increased dFC between the hippocampal head and the LN, at the expense of the SMN, may represent a marker of disease in patients with EDDs. Lower dFC between the SMN and the hippocampal body may represent a marker of vulnerability to EDDs in EDDoff that is correlated with ED. Such a transdiagnostic construct represents a clinically relevant target for early interventions aimed at reducing vulnerability to EDDs in high-risk populations.
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