Ifigeneia Barmpa, Apostolos Chatzitomaris, Eva Maria Lüngen, Ralf Lobmann
{"title":"[罕见的反复低血糖的原因]。","authors":"Ifigeneia Barmpa, Apostolos Chatzitomaris, Eva Maria Lüngen, Ralf Lobmann","doi":"10.1007/s00108-025-01889-2","DOIUrl":null,"url":null,"abstract":"<p><p>Non-islet cell tumor hypoglycemia (NICTH) is a rare cause of hypoglycemia, resulting from excessive secretion of insulin-like growth factor 2 (IGF-2) or pro-IGF‑2, which leads to subsequent activation of the insulin receptor. Doege-Potter syndrome is often used synonymously with NICTH, especially in cases with fibrous primary tumors in the thorax. In the current patient, tumor progression was observed over a short period without the possibility of debulking surgery. Therefore, oral therapy with prednisolone was initiated. Treatment with diazoxide or the somatostatin analogue octreotide is not recommended for NICTH.</p>","PeriodicalId":73385,"journal":{"name":"Innere Medizin (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Rare cause of recurrent hypoglycemia].\",\"authors\":\"Ifigeneia Barmpa, Apostolos Chatzitomaris, Eva Maria Lüngen, Ralf Lobmann\",\"doi\":\"10.1007/s00108-025-01889-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Non-islet cell tumor hypoglycemia (NICTH) is a rare cause of hypoglycemia, resulting from excessive secretion of insulin-like growth factor 2 (IGF-2) or pro-IGF‑2, which leads to subsequent activation of the insulin receptor. Doege-Potter syndrome is often used synonymously with NICTH, especially in cases with fibrous primary tumors in the thorax. In the current patient, tumor progression was observed over a short period without the possibility of debulking surgery. Therefore, oral therapy with prednisolone was initiated. Treatment with diazoxide or the somatostatin analogue octreotide is not recommended for NICTH.</p>\",\"PeriodicalId\":73385,\"journal\":{\"name\":\"Innere Medizin (Heidelberg, Germany)\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Innere Medizin (Heidelberg, Germany)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00108-025-01889-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Innere Medizin (Heidelberg, Germany)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00108-025-01889-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Non-islet cell tumor hypoglycemia (NICTH) is a rare cause of hypoglycemia, resulting from excessive secretion of insulin-like growth factor 2 (IGF-2) or pro-IGF‑2, which leads to subsequent activation of the insulin receptor. Doege-Potter syndrome is often used synonymously with NICTH, especially in cases with fibrous primary tumors in the thorax. In the current patient, tumor progression was observed over a short period without the possibility of debulking surgery. Therefore, oral therapy with prednisolone was initiated. Treatment with diazoxide or the somatostatin analogue octreotide is not recommended for NICTH.