肿瘤性癫痫的非肿瘤性杏仁核增大。

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

World neurosurgery Pub Date : 2025-03-29 DOI:10.1016/j.wneu.2025.123949

Subeikshanan Venkatesan , John Whalen , Giridhar Kalamangalam

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引用次数: 0

摘要

一位18岁的非裔美国左撇子男性，以发作性心悸、出汗和躁动为特征，表现出长达一年的癫痫发作史。脑MRI显示右侧前内嗅皮层一强化肿瘤伴邻近杏仁核肿大。脑间期磁图和视频脑电图证实病变性右颞叶癫痫。患者接受了部分右侧颞叶前部切除术，组织病理学显示为WHO 2级多形性黄色星形细胞瘤（PXA），伴有BRAF V600E突变。杏仁核未见肿瘤浸润，证实反应性增生而非肿瘤累及。本病例强调了在长期癫痫相关肿瘤（LEATs）中区分肿瘤浸润与良性癫痫相关杏仁核增大的重要性，这有助于指导手术策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nontumoral Amygdalar Enlargement in Tumoral Epilepsy

An 18-year-old left-handed African American male presented with a year-long history of seizures characterized by episodic palpitations, sweating, and agitation. Brain magnetic resonance imaging revealed an enhancing tumor in the right anterior entorhinal cortex with adjacent amygdalar enlargement. Interictal magnetoencephalography and video-electroencephalogram -confirmed lesional right temporal lobe epilepsy. The patient underwent a partial right anterior temporal lobectomy, with histopathology revealing WHO Grade 2 pleomorphic xanthoastrocytoma with a BRAF V600 E mutation. The amygdala showed no tumor infiltration, confirming reactive hyperplasia rather than neoplastic involvement. This case underscores the importance of distinguishing tumor infiltration from benign seizure-related amygdalar enlargement in long-term epilepsy-associated tumors, usefully informing surgical strategy.

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来源期刊

World neurosurgery CLINICAL NEUROLOGY-SURGERY

CiteScore

3.90

自引率

15.00%

发文量

1765

审稿时长

47 days

期刊介绍： World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS