MicroRNA作为家畜生理和应激处理的生物标志物。

IF 1.6 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Montaser Elsayed Ali, Fatimah A Al-Saeed, Ahmed Ezzat Ahmed, Min Gao, Wei Wang, Haimiao Lv, Guohua Hua, Liguo Yang, Mohamed Abdelrahman
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引用次数: 0

摘要

自1993年以来,microrna (mirna)作为一种潜在的生物标记物被广泛发现,已成为分子生物学研究的一个重要领域。由于它们具有激活细胞外分子、稳定身体组织、控制细胞间信号和易于提取的能力,mirna被公认为生物标志物。然而,人们越来越关注靶向mirna来监测生理生殖性能,包括生殖系统发育、胚胎发育、受精、内分泌学和应激条件下的动物福利。此外,mirna在基因表达调控中发挥着重要作用;单个mirna可能具有重叠的作用,并且在更广泛的范围内,多个mrna控制单个功能。此外,mirna作为环境和生殖性能之间的中介信使,使其成为mirna在热应激等环境条件下作为性能生物标志物的重要组成部分。这使得描述一个独特的miRNA的后果和功能非常具有挑战性,这可能使许多研究人员感到困惑。此外,增强我们对睾丸热应激反应中mirna的理解可能有助于预防和治疗精子发生障碍。因此,本文就热应激条件下miRNA对生殖性能的调控机制进行综述,以期将这些发现应用于生殖生理学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MicroRNA as Biomarkers for Physiological and Stress Processing in the Livestock.

Several microRNAs (miRNAs) have been identified as potential biomarkers widely dispersed in animals since 1993, and they have become a significant molecular biology research area. Because of their ability to activate extracellular molecules, stabilise bodily tissues, control cell-to-cell signals, and be easily extracted, miRNAs are outstandingly nominated as biomarkers. However, there is growing interest in targeting miRNAs to monitor physiological reproductive performance, including reproductive system development, embryo development, fertilisation, endocrinology, and animal welfare in stressful conditions. Moreover, miRNAs play significant roles in gene expression regulation; single miRNAs may have overlapping roles, and on a broader scale, multiple mRNAs govern a single function. Also, miRNAs serve as an intermediary messenger between the environment and reproductive performance, making them a vital component of miRNAs as performance biomarkers under environmental conditions like heat stress. This makes describing a unique miRNA's consequences and functions exceptionally challenging, which may confound many researchers. Also, enhancing our comprehension of miRNAs in response to testicular heat stress could potentially aid in preventing and treating spermatogenesis disorders. Therefore, the present review highlights miRNA's regulatory mechanisms on reproductive performance under heat stress to employ these findings in improving reproduction physiology research.

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来源期刊
Reproduction in Domestic Animals
Reproduction in Domestic Animals 农林科学-奶制品与动物科学
CiteScore
3.00
自引率
5.90%
发文量
238
审稿时长
4-8 weeks
期刊介绍: The journal offers comprehensive information concerning physiology, pathology, and biotechnology of reproduction. Topical results are currently published in original papers, reviews, and short communications with particular attention to investigations on practicable techniques. Carefully selected reports, e. g. on embryo transfer and associated biotechnologies, gene transfer, and spermatology provide a link between basic research and clinical application. The journal applies to breeders, veterinarians, and biologists, and is also of interest in human medicine. Interdisciplinary cooperation is documented in the proceedings of the joint annual meetings. Fields of interest: Animal reproduction and biotechnology with special regard to investigations on applied and clinical research.
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