女性癌症患者的生育能力保存:评估意识,态度,关注,经验,以及咨询在生活质量中的作用。

IF 3.2 3区 医学 Q2 GENETICS & HEREDITY
Eman Sbaity, Nagham Ramadan, Ali Slim, Tasnim Diab, Houry Kazarian, Ali Tarhini, Maya Charafeddine, Ghina Ghazeeri, Ali Bazarbachi, Jean El Cheikh, Nagi S El Saghir, Hazem I Assi
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引用次数: 0

摘要

背景:癌症对育龄妇女的生育能力构成了重大挑战,但生育能力保存(FP)措施的采用仍然有限。本研究旨在探讨患者在治疗期间对计划生育的理解、态度、关注、心理健康状况以及影响其决策的因素。方法:这项前瞻性队列研究纳入了在贝鲁特美国大学医学中心接受治疗的18 - 42岁确诊为非转移性乳腺癌或淋巴瘤的女性。患者在诊断后的2至3年内完成问卷调查。结果:调查的123名女性中,71.5%已婚,13.5%无子女。尽管87.8%的人被告知其治疗的生育风险,但只有45.4%的人表示希望进行计划生育。多变量分析显示胎次与生育问题显著相关(p = 0.019)。结论:我们的研究强调了癌症幸存者计划生育决策的复杂性,强调需要适当的咨询来支持他们的生活质量和心理健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fertility preservation in female cancer patients: assessing awareness, attitudes, concerns, experiences, and the role of counseling in quality of life.

Background: Cancer poses significant fertility challenges for women of childbearing age, yet the adoption of fertility preservation (FP) measures remains limited. This study aimed to explore patients' understanding, attitudes, concerns, psychological well-being, and factors influencing their decisions regarding FP during treatment.

Methods: This prospective cohort study involved women aged 18 to 42 diagnosed with non-metastatic breast cancer or lymphoma, treated at the American University of Beirut Medical Center. Patients completed questionnaires at intervals over a 2- to 3-year period following diagnosis.

Results: Among the 123 women studied, 71.5% were married, and 13.5% had no children. Although 87.8% were informed about the fertility risks of their treatment, only 45.4% expressed a desire for FP. Multivariable analysis revealed that parity was significantly associated with fertility concerns (p = 0.019). Decisions favoring FP were significantly influenced by younger age at diagnosis, lower parity, and higher education levels (p = 0.001, p < 0.001, and p = 0.036, respectively). While 56% of patients received FP counseling-mostly from oncologists (83%)-the preference for FP methods varied, with 47% choosing medical approaches and 53% opting for procedural interventions. Despite recognizing the importance of FP, 91% reported that it did not significantly influence their treatment choices. Patients showed greater satisfaction when oncologists discussed fertility-related topics (p < 0.001). Over time, overall FertiQoL scores and DASS-42 scores indicated improved psychological well-being.

Conclusion: Our study highlights the complexities of FP decisions among cancer survivors, emphasizing the need for proper counseling to support their quality of life and psychological well-being.

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来源期刊
CiteScore
5.70
自引率
9.70%
发文量
286
审稿时长
1 months
期刊介绍: The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.
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