预防结核分枝杆菌感染的见解：是时候正式确认另一种表型了？

IF 13.3 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of Clinical Investigation Pub Date : 2025-04-01 DOI:10.1172/JCI191423

Todia P Setiabudiawan, Philip C Hill, Andrew R DiNardo, Reinout van Crevel

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引用次数: 0

摘要

预防结核分枝杆菌（Mtb）感染的免疫相关因素仍然难以捉摸。在这一期的JCI中，Dallmann-Sauer和作者证明，尽管长期暴露于Mtb，但艾滋病毒感染者缺乏结核菌素皮肤试验（TST）和干扰素γ释放试验（IGRA）转换与肺泡淋巴细胞增多有关，包括特异性多细胞毒性T细胞和m1型肺泡巨噬细胞对病原体有更强的体外反应。对这些被称为“结核抵抗者”的罕见个体以及在特定接触事件（称为“早期清除者”）后几个月内反复呈IGRA阴性的结核病家庭接触者进行的研究有助于阐明可操作的机制，以加强对结核杆菌感染的保护。

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Insights into protection against Mycobacterium tuberculosis infection: time to officially confirm another phenotype?

Immune correlates of protection against infection with Mycobacterium tuberculosis (Mtb) remain elusive. In this issue of the JCI, Dallmann-Sauer and authors demonstrate that lack of tuberculin skin test (TST) and interferon γ release assay (IGRA) conversion among people with HIV despite years-long Mtb exposure is associated with alveolar lymphocytosis, including specific poly-cytotoxic T cells, and M1-type alveolar macrophages with a stronger ex vivo response to the pathogen. Studies in these rare individuals, termed "TB resisters" and in tuberculosis household contacts who are repeatedly IGRA negative in the months after a specific exposure event (known as "early clearers") help elucidate manipulatable mechanisms to boost protection against Mtb infection.

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来源期刊

Journal of Clinical Investigation 医学-医学：研究与实验

CiteScore

24.50

自引率

1.30%

发文量

1034

审稿时长

2 months

期刊介绍： The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.