血浆白细胞介素-1家族浓度与极早产儿支气管肺发育不良的动态关联。

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-03-30 DOI:10.1038/s41372-025-02275-4

Qingling Li, Cuihui Li, Yunbei Rao, Dongshan Han, Xuan Wang, Lingling Yang, Yiran Chen, Chuanzhong Yang, Xueyu Chen

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引用次数: 0

摘要

目的：评价极早产儿IL-1α、IL-1β和IL-1Ra的纵向变化，探讨其与支气管肺发育不良（BPD）的动态关系。方法：采集极早产儿产后7周、28周和36周的血浆样本。采用Bio-Plex Pro （human cytokine panel）检测IL-1细胞因子浓度。通过单因素和多因素logistic回归分析，探讨细胞因子与BPD的关系。结果：与非BPD婴儿相比，BPD婴儿在PD 28时IL-1α (10.75 vs. 8.18 pg/ml, p = 0.026)、IL-1β (2.00 vs. 1.50 pg/ml, p = 0.046)和IL-1Ra （878.50 vs. 262.40 pg/ml, p = 0.011）的浓度显著高于非BPD婴儿。PD 28时较高的IL-1α浓度（≥8.09 pg/ml）与BPD的发展独立相关（OR: 8.272, 95% CI: 1.127-60.705, p = 0.038）。结论：PD 28时IL-1α浓度升高与BPD风险增加独立相关。

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Dynamic association between plasma interleukin-1 family concentrations and bronchopulmonary dysplasia in extremely premature infants.

Objective: To evaluate the longitudinal changes of IL-1α, IL-1β, and IL-1Ra in extremely preterm infants and investigate the dynamic association with bronchopulmonary dysplasia (BPD).

Methods: Plasma samples were collected from extremely preterm infants at postnatal day (PD) 7,28 and PMA 36 weeks. IL-1 cytokines concentrations were measured by Bio-Plex Pro (human cytokine panel). Univariate and multivariate logistic regression analysis were conducted to explore the association between the cytokines and BPD.

Results: BPD infants exhibited significantly higher concentrations of IL-1α (10.75 vs. 8.18 pg/ml, p = 0.026), IL-1β (2.00 vs. 1.50 pg/ml, p = 0.046), and IL-1Ra (878.50 vs. 262.40 pg/ml, p = 0.011) compared to non-BPD infants at PD 28. Higher IL-1α concentration (≥8.09 pg/ml) at PD 28 was independently associated with BPD development (OR: 8.272, 95% CI: 1.127-60.705, p = 0.038).

Conclusions: Increased IL-1α concentrations at PD 28 were independently associated with an increased risk of BPD.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.