{"title":"COVID-19对年轻人的长期健康影响：关注呼吸和心血管耐力","authors":"Manohara H G, Megha Bhat Agni, Damodara Gowda K M","doi":"10.1007/s11845-025-03950-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has significantly impacted health, extending beyond the acute phase of illness. Among young adults, \"long COVID\" has raised concerns regarding respiratory and cardiovascular endurance. This study evaluates pulmonary function test (PFT), distance travelled in the 6-min walk test (6MWT), and changes in SpO2 and respiratory rate before and after 6MWT in COVID-19 convalescent patients compared to healthy controls.</p><p><strong>Methods: </strong>This case-control study included 45 controls and 45 COVID-19 convalescent patients confirmed by RT-PCR. Data on PFT, distance travelled in 6MWT, SpO2, and respiratory rate were collected. The associations were analyzed using the Student t-test and ANOVA, with p < 0.05 considered significant.</p><p><strong>Results: </strong>Significant reductions were observed in FVC (p = 0.02), FEV<sub>1</sub> (p = 0.007), FEF<sub>25%</sub> (p = 0.0001), FEF<sub>50%</sub> (p = 0.003), FEF<sub>25-75%</sub> (p = 0.02), and PEFR (p = 0.0001), with an increased lung age (p = 0.01) in COVID-19 convalescent patients compared to controls. No significant difference was observed in FEV<sub>1</sub>/FVC ratio, FEV<sub>3</sub>, FEV<sub>3</sub>/FVC ratio, or FEF<sub>75%</sub>. While percentage saturation of oxygen, respiratory rate, and distance travelled in 6MWT showed no significant differences between groups, respiratory rate (p = 0.0001) and pulse rate (p = 0.001) differed significantly before and after 6MWT.</p><p><strong>Conclusions: </strong>COVID-19 convalescent patients exhibited significant declines in FVC, FEV<sub>1</sub>, FEF<sub>25%</sub>, FEF<sub>50%</sub>, and FEF<sub>25-75%</sub>, indicating potential restrictive or obstructive lung defects. Increased lung age also suggests long-term impacts of SARS-CoV-2 on respiratory performance.</p>","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term health consequences of COVID-19 in young adults: a focus on respiratory and cardiovascular endurance.\",\"authors\":\"Manohara H G, Megha Bhat Agni, Damodara Gowda K M\",\"doi\":\"10.1007/s11845-025-03950-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The COVID-19 pandemic has significantly impacted health, extending beyond the acute phase of illness. Among young adults, \\\"long COVID\\\" has raised concerns regarding respiratory and cardiovascular endurance. This study evaluates pulmonary function test (PFT), distance travelled in the 6-min walk test (6MWT), and changes in SpO2 and respiratory rate before and after 6MWT in COVID-19 convalescent patients compared to healthy controls.</p><p><strong>Methods: </strong>This case-control study included 45 controls and 45 COVID-19 convalescent patients confirmed by RT-PCR. Data on PFT, distance travelled in 6MWT, SpO2, and respiratory rate were collected. The associations were analyzed using the Student t-test and ANOVA, with p < 0.05 considered significant.</p><p><strong>Results: </strong>Significant reductions were observed in FVC (p = 0.02), FEV<sub>1</sub> (p = 0.007), FEF<sub>25%</sub> (p = 0.0001), FEF<sub>50%</sub> (p = 0.003), FEF<sub>25-75%</sub> (p = 0.02), and PEFR (p = 0.0001), with an increased lung age (p = 0.01) in COVID-19 convalescent patients compared to controls. No significant difference was observed in FEV<sub>1</sub>/FVC ratio, FEV<sub>3</sub>, FEV<sub>3</sub>/FVC ratio, or FEF<sub>75%</sub>. While percentage saturation of oxygen, respiratory rate, and distance travelled in 6MWT showed no significant differences between groups, respiratory rate (p = 0.0001) and pulse rate (p = 0.001) differed significantly before and after 6MWT.</p><p><strong>Conclusions: </strong>COVID-19 convalescent patients exhibited significant declines in FVC, FEV<sub>1</sub>, FEF<sub>25%</sub>, FEF<sub>50%</sub>, and FEF<sub>25-75%</sub>, indicating potential restrictive or obstructive lung defects. Increased lung age also suggests long-term impacts of SARS-CoV-2 on respiratory performance.</p>\",\"PeriodicalId\":14507,\"journal\":{\"name\":\"Irish Journal of Medical Science\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Irish Journal of Medical Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11845-025-03950-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Irish Journal of Medical Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11845-025-03950-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Long-term health consequences of COVID-19 in young adults: a focus on respiratory and cardiovascular endurance.
Introduction: The COVID-19 pandemic has significantly impacted health, extending beyond the acute phase of illness. Among young adults, "long COVID" has raised concerns regarding respiratory and cardiovascular endurance. This study evaluates pulmonary function test (PFT), distance travelled in the 6-min walk test (6MWT), and changes in SpO2 and respiratory rate before and after 6MWT in COVID-19 convalescent patients compared to healthy controls.
Methods: This case-control study included 45 controls and 45 COVID-19 convalescent patients confirmed by RT-PCR. Data on PFT, distance travelled in 6MWT, SpO2, and respiratory rate were collected. The associations were analyzed using the Student t-test and ANOVA, with p < 0.05 considered significant.
Results: Significant reductions were observed in FVC (p = 0.02), FEV1 (p = 0.007), FEF25% (p = 0.0001), FEF50% (p = 0.003), FEF25-75% (p = 0.02), and PEFR (p = 0.0001), with an increased lung age (p = 0.01) in COVID-19 convalescent patients compared to controls. No significant difference was observed in FEV1/FVC ratio, FEV3, FEV3/FVC ratio, or FEF75%. While percentage saturation of oxygen, respiratory rate, and distance travelled in 6MWT showed no significant differences between groups, respiratory rate (p = 0.0001) and pulse rate (p = 0.001) differed significantly before and after 6MWT.
Conclusions: COVID-19 convalescent patients exhibited significant declines in FVC, FEV1, FEF25%, FEF50%, and FEF25-75%, indicating potential restrictive or obstructive lung defects. Increased lung age also suggests long-term impacts of SARS-CoV-2 on respiratory performance.
期刊介绍：
The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker.
The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.
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