长期耻骨上膀胱造口的鳞状细胞癌:泌尿学的奇事。

IF 0.5 Q4 ONCOLOGY
International Cancer Conference Journal Pub Date : 2025-01-06 eCollection Date: 2025-04-01 DOI:10.1007/s13691-024-00743-w
Rajat Choudhari, Kamal Kishor Lakhera, Suresh Singh, Pinakin Patel, Naina Kumar, Yashasvi Patel
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引用次数: 0

摘要

鳞状细胞癌(SCC)很少占膀胱癌的2-5%。膀胱感染或留置导尿管引起的慢性刺激是SCC的危险因素。只有少数耻骨上膀胱造口术(SPC)部位的SCC已被报道,并且通常见于截瘫或需要长期导尿的尿道狭窄。我们报告一例69岁男性患者,因尿道狭窄而留腔25年,在尿道狭窄周围出现真菌生长,并包裹导管,证实为鳞状细胞癌。影像显示累及腹壁及膀胱,无转移扩散。他接受了广泛的局部切除(WLE)病变,根治性膀胱切除术和回肠导管重建,双侧髂-腹股沟淋巴结切除术和带蒂的大腿前外侧皮瓣腹壁重建。患者接受辅助放疗,3个月无复发。在既往报道的12例病例中,9例采用手术治疗,其中4例联合部分膀胱切除术,4例联合根治性膀胱切除术。SCC往往局限于导管周围并进入腹腔,广泛的手术切除提供了治愈的最大希望。定期的膀胱镜检查和导管周围的膀胱活检可以帮助早期发现,治疗应该因人而异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Squamous cell carcinoma in a long-standing suprapubic cystostomy: a urological oddball.

Squamous cell carcinoma (SCC) rarely accounts for 2-5% of urinary bladder cancer. Chronic irritation of the bladder from infection or indwelling catheter is a risk factor for SCC. Only a handful of cases of suprapubic cystostomy (SPC) site SCC have been reported and have been always seen in paraplegics or urethral stricture requiring long-standing catheterization. We report a case of a 69-year-old male with an indwelling (SPC) of 25 years duration for a urethral stricture who presented with a fungating growth around the SPC site enveloping the catheter confirmed to be squamous cell carcinoma. Imaging revealed involvement of abdominal wall and urinary bladder with no metastatic spread. He underwent wide local excision (WLE) of the lesion with radical cystectomy and ileal conduit reconstruction with bilateral ilio-inguinal lymphadenectomy and pedicled anterolateral thigh flap for abdominal wall reconstruction. He received adjuvant radiotherapy and was found to be recurrence free at 3 months. Among the cases previously reported, 9 of the 12 cases were treated surgically with 4 of those combined with partial cystectomy and 4 with radical cystectomy. SPC site SCC tends to be localized around the catheter and into the abdominal tract and wide surgical excision offers the best hope for cure. Regular cystoscopy and biopsy from bladder around the catheter site can help early detection and the treatment should be personalized to each patient.

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来源期刊
自引率
14.30%
发文量
57
期刊介绍: This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)
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