THE IMPACT OF BARIATRIC SURGERY ON TYPE 2 DIABETES MELLITUS REMISSION IN THE GEORGIAN POPULATION.

Background: Obesity and diabetes are two closely related diseases that increase morbidity and mortality. Our study aims to investigate the effect of bariatric surgery on diabetes remission.

Methods: We studied 91 patients with type 2 diabetes mellitus (T2DM) and morbid obesity who underwent bariatric surgery-sleeve gastrectomy-at the "David Abuladze Georgian-Italian Clinic" from 2015-2022. The patients' ages ranged from 23 to 67 years (46.67±8.60), including 50 women and 41 men.

Results: After the surgery, all patients reported weight loss (kg): before the surgery 146.80±25.81, after the surgery 97.87±17.56. t= 23.30, p <0.0001 the relative chance of remission after bariatric surgery increases Weight (kg) - OR=1.03(95% CI:1,02-1.05) and reduce Glycemia - Fasting >125 mg /dL - OR=0.06(95% CI:0.01-0.60); Sulfonylurea - OR=0.07(95% CI:0.02-0.27); Insulin - OR=0.06(95% CI:0.01-0.56) Conclusions: • Bariatric surgery in patients with type 2 diabetes promotes long-term remission of diabetes. • Positive predictor of complete remission is the patient's initial weight before bariatric surgery. Treatment and high glycemia (fasting >125 mg/dL) before surgery reduce the relative probability of complete remission. • Weight loss as a predictor of complete remission shows high sensitivity and specificity (cutoff value = 37.5kg).