细胞去分化。重温贝蒂·海的遗产。

IF 2.5 3区生物学 Q2 DEVELOPMENTAL BIOLOGY

Developmental biology Pub Date : 2025-03-29 DOI:10.1016/j.ydbio.2025.03.017

Alejandra Beltrán-Rivera, José E. García-Arrarás

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引用次数: 0

摘要

1959年发表的Elizabeth Hay对两栖动物肢体再生的开创性观察从根本上挑战了成熟特化细胞和分化状态稳定性的概念。在C.S. Thornton先前工作的基础上，她发现肌肉细胞可以去分化并转化为再生胚内的祖细胞，重塑了我们对细胞分化的理解。这一关键发现重塑了我们对细胞分化的理解，开辟了新的研究途径。尽管存在争议，但她的发现极大地推动了细胞可塑性和再生生物学领域的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cellular dedifferentiation. Revisiting Betty Hay's legacy

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Cellular dedifferentiation. Revisiting Betty Hay's legacy

The concept of mature specialized cells and the stability of the differentiated state was fundamentally challenged by Elizabeth Hay's groundbreaking observations on amphibian limb regeneration, published in 1959. Building on previous work by C.S. Thornton, she discovered that muscle cells could dedifferentiate and transform into progenitor cells within the regeneration blastema reshaping our understanding of cell differentiation. This pivotal finding reshaped our understanding of cell differentiation, opening new avenues of research. Though controversial, her findings significantly advanced the fields of cell plasticity and regenerative biology.

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来源期刊

Developmental biology 生物-发育生物学

CiteScore

5.30

自引率

3.70%

发文量

182

审稿时长

1.5 months

期刊介绍： Developmental Biology (DB) publishes original research on mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning, cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals.