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IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Frontiers in Cardiovascular Medicine Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI:10.3389/fcvm.2025.1545100

Run-Tian Meng, Qiao-Wen Chen, Chih-Yuan Ko

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引用次数: 0

摘要

研究目的本研究探讨了血液胱抑素-C（Cys-C）和单核细胞与高密度脂蛋白胆固醇比值（MHR）这两种公认的炎症标志物与男性患者阻塞性睡眠呼吸暂停（OSA）严重程度之间的关系：共纳入117名在2019年2月至2022年12月期间接受过夜间多导睡眠图（PSG）检查的男性参与者。根据呼吸暂停-低通气指数（AHI），参与者被分为三组：G1（AHI n = 9；对照组）、G2（5 ≤ AHI n = 32）和G3（AHI ≥ 30 次/小时，n = 76）。测量血清 Cys-C 和 MHR 水平并分析其与 OSA 严重程度的相关性。多变量逻辑回归和接收者操作特征（ROC）分析评估了它们的诊断价值，而限制性三次样条（RCS）分析则检查了潜在的非线性关系：结果：Cys-C 和 MHR 水平随 OSA 严重程度的增加而增加，并与 AHI 呈显著正相关（Cys-C：r = 0.084，P r = 0.1286，P P = 0.008），而在调整混杂因素后，Cys-C 失去了统计学意义。RCS 分析未发现明显的非线性关系（P > 0.05）。ROC 分析显示，结合 Cys-C 和 MHR 可适度提高诊断准确性（AUC = 0.6622，95% CI：0.554-0.77）。亚组分析表明，与无高血压患者相比，严重OSA患者的Cys-C和MHR水平更高，但差异无统计学意义（P > 0.05）：结论：Cys-C 和 MHR 与 OSA 的严重程度呈正相关，其中 MHR 是更强的独立生物标志物。将这些标志物纳入 OSA 风险分层可加强临床评估和有针对性的干预措施。未来需要进行大规模的前瞻性研究，以验证它们的预后价值和临床实用性。

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Evaluating cystatin-C and monocyte-to-high-density lipoprotein cholesterol ratio as indicators of obstructive sleep apnea severity in male patients.

Objectives: This study investigates the association between blood cystatin-C (Cys-C) and monocyte-to-high-density lipoprotein cholesterol ratio (MHR), both established inflammatory markers, with the severity of obstructive sleep apnea (OSA) in male patients.

Methods: A total of 117 male participants who underwent overnight polysomnography (PSG) between February 2019 and December 2022 were included. Based on the apnea-hypopnea index (AHI), participants were categorized into three groups: G1 (AHI < 5 events/hour, n = 9; control group), G2 (5 ≤ AHI < 30 events/hour, n = 32), and G3 (AHI ≥ 30 events/hour, n = 76). Serum Cys-C and MHR levels were measured and analyzed for their correlation with OSA severity. Multivariate logistic regression and receiver operating characteristic (ROC) analyses assessed their diagnostic value, while restricted cubic spline (RCS) analysis examined potential nonlinear relationships.

Results: Cys-C and MHR levels increased with OSA severity and showed significant positive correlations with AHI (Cys-C: r = 0.084, P < 0.05; MHR: r = 0.1286, P < 0.05). In multivariate regression, MHR remained an independent correlate of OSA severity (adjusted OR = 47.130, 95% CI: 1.014-6.692, P = 0.008), whereas Cys-C lost statistical significance after adjusting for confounders. RCS analysis found no significant nonlinear relationship (P > 0.05). ROC analysis showed that combining Cys-C and MHR modestly improved diagnostic accuracy (AUC = 0.6622, 95% CI: 0.554-0.77). Subgroup analysis indicated that severe OSA patients with hypertension had higher Cys-C and MHR levels compared to those without hypertension, though the differences were not statistically significant (P > 0.05).

Conclusions: Cys-C and MHR are positively associated with OSA severity, with MHR emerging as a stronger independent biomarker. Incorporating these markers into OSA risk stratification may enhance clinical assessment and targeted interventions. Future large-scale prospective studies are needed to validate their prognostic value and clinical utility.

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来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.