{"title":"家族性额部纤维性脱发在母亲患病的女儿中发生得早:一个病例报告和文献回顾。","authors":"Adrienne Oxenham, Annabel Stevenson","doi":"10.1111/ajd.14463","DOIUrl":null,"url":null,"abstract":"<p><p>Frontal fibrosing alopecia (FFA) is a form of cicatricial alopecia that is being increasingly diagnosed in recent years. It predominantly affects post-menopausal women of various ethnic backgrounds, but cases have also been reported in pre-menopausal women and rarely in men. Eleven familial cases of FFA have been published in the literature, with some authors raising speculation about potential genetic predisposition or shared exposure to environmental factors as triggers for the condition. Despite this, there remains a lack of detailed characterisation of the clinical features specific to familial cases of FFA. In this report, we aim to contribute to the understanding of FFA by presenting the first Australian case of familial FFA involving a mother and her daughter, while also attempting to define the clinical distinguishing features in familial FFA and sporadic FFA.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":"247-257"},"PeriodicalIF":1.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334806/pdf/","citationCount":"0","resultStr":"{\"title\":\"Familial Frontal Fibrosing Alopecia Occurs Early in Daughters With Affected Mothers: A Case Report and a Review of the Literature.\",\"authors\":\"Adrienne Oxenham, Annabel Stevenson\",\"doi\":\"10.1111/ajd.14463\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Frontal fibrosing alopecia (FFA) is a form of cicatricial alopecia that is being increasingly diagnosed in recent years. It predominantly affects post-menopausal women of various ethnic backgrounds, but cases have also been reported in pre-menopausal women and rarely in men. Eleven familial cases of FFA have been published in the literature, with some authors raising speculation about potential genetic predisposition or shared exposure to environmental factors as triggers for the condition. Despite this, there remains a lack of detailed characterisation of the clinical features specific to familial cases of FFA. In this report, we aim to contribute to the understanding of FFA by presenting the first Australian case of familial FFA involving a mother and her daughter, while also attempting to define the clinical distinguishing features in familial FFA and sporadic FFA.</p>\",\"PeriodicalId\":8638,\"journal\":{\"name\":\"Australasian Journal of Dermatology\",\"volume\":\" \",\"pages\":\"247-257\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334806/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Australasian Journal of Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/ajd.14463\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Australasian Journal of Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ajd.14463","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Familial Frontal Fibrosing Alopecia Occurs Early in Daughters With Affected Mothers: A Case Report and a Review of the Literature.
Frontal fibrosing alopecia (FFA) is a form of cicatricial alopecia that is being increasingly diagnosed in recent years. It predominantly affects post-menopausal women of various ethnic backgrounds, but cases have also been reported in pre-menopausal women and rarely in men. Eleven familial cases of FFA have been published in the literature, with some authors raising speculation about potential genetic predisposition or shared exposure to environmental factors as triggers for the condition. Despite this, there remains a lack of detailed characterisation of the clinical features specific to familial cases of FFA. In this report, we aim to contribute to the understanding of FFA by presenting the first Australian case of familial FFA involving a mother and her daughter, while also attempting to define the clinical distinguishing features in familial FFA and sporadic FFA.
期刊介绍:
Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.