Abdo Mohammed Mohammed Abdulrazzaq, Sultan Alanazi, Ali M Alyami, Abdullah Awad Alshehri, Turki Fahad Al Mansour, Yazeed Saleh Al-Ghwaynim
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Geno-toxic risk assessment of locally produced bovine pericardium (LYOLEMB) for guided tissue regeneration.
This study evaluated the genotoxic risk of locally produced bovine pericardium (LYOLEMB) as a guided tissue regeneration (GTR) material for advanced periodontal disease using the Ames test with metabolic activation (a sodium phosphate buffer). Mutagenic effects on Salmonella typhimurium strains TA 98, TA 1537, TA 100 and TA 1535 at concentrations ranging from 0.3125 mg/plate to 5 mg/plate showed no significant genotoxicity, with revertant counts remaining below twice that of the control. Statistical significance was observed near p ≤ 0.05 at certain concentrations, confirming LYOLEMB's non-mutagenic, biocompatible and safe use in periodontal therapy.
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