聚集诱导发射生物偶联物的研究进展。

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-04-01 DOI:10.1021/acs.bioconjchem.5c00036

Guiquan Zhang, Daming Zhou, Rong Hu, Anjun Qin, Ben Zhong Tang

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引用次数: 0

摘要

荧光成像技术在现代个体化、精准化医疗中发挥着越来越重要的作用。由于其优异的光物理性能，具有聚集诱导发射（AIE）特性的有机发光源（AIEgens）在过去的二十年中受到了广泛的关注。由于AIE生物偶联物具有优异的生物相容性、易于加工和功能化、优异的水溶性、高响应性和对生物靶点的特殊信噪比（SNR）， AIE生物偶联物通过AIE原与生物分子共价连接形成，已成为生物应用的理想候选物。本文综述了近五年来AIE生物偶联物的制备、性质及应用进展。此外，还简要讨论了AIE生物偶联物面临的挑战和机遇。

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Recent Advances in Aggregation-Induced Emission Bioconjugates.

Fluorescence imaging technology is playing increasing roles in modern personalized and precision medicine. Thanks to their excellent photophysical properties, organic luminogens featuring aggregation-induced emission (AIE) characteristics (AIEgens) have attracted considerable attention over the past two decades. Because of their superior biocompatibility, ease of processing and functionalization, excellent water solubility, high responsiveness, and exceptional signal-to-noise ratio (SNR) for biotargets, AIE bioconjugates, formed by covalently linking AIEgens with biomolecules, have emerged as an ideal candidate for bioapplications. In this review, we summarize the progress in preparation, properties, and application of AIE bioconjugates in the last five years. Moreover, the challenges and opportunities of AIE bioconjugates are also briefly discussed.

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.