氧化多组分环化反应发散合成四类熔融含n杂环化合物

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-01-31 DOI:10.1002/cjoc.202401209

Xiaoshuang Guo, Maozhong Miao, Peng Zhao, Yongmin Ma

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引用次数: 0

摘要

以醇类和3-氨基吡唑为原料，采用大气-氧介导的四组分反应，合成了吡唑[1,5-a]嘧啶和吡唑[3,4-b]吡啶衍生物。在这一转化过程中，大气中的氧气作为绿色氧化剂，促进醇类作为等价醛类合成四种含n杂环（40例）。值得注意的是，这种转化具有无金属和分子多样性的特点。

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Divergent Synthesis of Four Types of Fused N-Containing Heterocycles via Oxidative Multi-Component Cyclization Reaction

An atmospheric-oxygen-mediated four-component reaction was developed for the divergent synthesis of pyrazolo[1,5-a]pyrimidine and pyrazolo[3,4-b]pyridine derivatives from readily available alcohols and 3-aminopyrazoles. In this transformation, atmospheric oxygen serves as the green oxidant, promoting alcohols as equivalent aldehydes for the synthesis of four types of N-containing heterocycles (> 40 examples). Remarkably, the transformation features metal-free and molecular diversity.

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.