Isatis glauca Aucher Ex Boiss。无性系种群。靛蓝提取物作为酶抑制剂的生物化学研究

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Beyza Sevdenur Nezir, Edanur Dasdemir, Tuba Aydın, Ruya Saglamtas, Elife Kaya, Fevzi Ozgokce
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引用次数: 0

摘要

Isatis glauca Aucher ex Boiss。无性系种群。青蓝是一种天然生长在泰国的靛蓝。本研究首次对青花菊的体外生物活性进行了评价。研究了青花草甲醇、乙醇、二氯甲烷/甲醇(50:50)、丙酮、乙酸乙酯、二氯甲烷和正己烷提取物对人碳酸酐酶I (hCAI)、人碳酸酐酶II (hCAII)、乙酰胆碱酯酶(AChE)、丁基胆碱酯酶(BChE)和α-糖苷酶的抑制作用。计算IC50值来确定提取物的抑制作用。其中,对hCAI、hCAII、AChE、BChE和α-葡萄糖苷酶的抑制活性最强的分别是乙酸乙酯提取物(IC50: 75.77 mg/mL)、甲醇提取物(IC50: 102.89 mg/mL)、正己烷提取物(IC50: 61.11 mg/mL)、乙酸乙酯提取物(IC50: 22.79 mg/mL)和乙酸乙酯提取物(IC50: 77.12 mg/mL)。研究结果表明,青花的所有提取物都可能具有良好的治疗作用。特别是,可以建议这些提取物具有用于治疗疾病或减轻症状的潜力。然而,需要进一步的研究和临床试验来确定其有效性。青花草植物化学物质的分离是今后研究的重点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Isatis glauca Aucher Ex Boiss. Subsp. Glauca (Indigo) Extracts as Enzyme Inhibitors: A Biochemical Study

Isatis glauca Aucher Ex Boiss. Subsp. Glauca (Indigo) Extracts as Enzyme Inhibitors: A Biochemical Study

Isatis glauca Aucher Ex Boiss. Subsp. Glauca (Indigo) Extracts as Enzyme Inhibitors: A Biochemical Study

Isatis glauca Aucher Ex Boiss. Subsp. Glauca (Indigo) Extracts as Enzyme Inhibitors: A Biochemical Study

Isatis glauca Aucher Ex Boiss. Subsp. Glauca (Indigo) Extracts as Enzyme Inhibitors: A Biochemical Study

Isatis glauca Aucher ex Boiss. subsp. glauca is a species of indigo that grows naturally in Türkiye. In this study, the in vitro biological activities of I. glauca were evaluated for the first time. The inhibitory effects of I. glauca’s methanol, ethanol, dichloromethane/methanol (50:50), acetone, ethyl acetate, dichloromethane, and n-hexane extracts were investigated on the enzymes human carbonic anhydrase I (hCAI), human carbonic anhydrase II (hCAII), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glycosidase. IC50 values were calculated to determine the inhibitory effect of the extracts. Among the extracts, the ones with the strongest inhibitory activity against hCAI, hCAII, AChE, BChE, and α-glucosidase were found to be ethyl acetate extract (IC50: 75.77 mg/mL), methanol extract (IC50: 102.89 mg/mL), n-hexane extract (IC50: 61.11 mg/mL), ethyl acetate extract (IC50: 22.79 mg/mL), and ethyl acetate extract (IC50: 77.12 mg/mL), respectively. The study findings suggest that all extracts of I. glauca may have promising therapeutic properties. In particular, it can be suggested that these extracts have the potential to be used in the treatment of diseases or the alleviation of symptoms. However, additional research and clinical trials are required to determine its efficacy. The isolation of I. glauca phytochemicals should be addressed in future studies.

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来源期刊
ChemistrySelect
ChemistrySelect Chemistry-General Chemistry
CiteScore
3.30
自引率
4.80%
发文量
1809
审稿时长
1.6 months
期刊介绍: ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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