人类松果体切除术综合征和褪黑素替代治疗的影响:1-心血管功能

IF 8.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Claudia Cosentino, Fernanda Gaspar do Amaral, Luciana Aparecida Campos, Fernanda Gentil, Osmar Pinto Neto, Andréa Maria Cappellano, Nasjla Saba da Silva, Ovidiu Constantin Baltatu, José Cipolla-Neto
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引用次数: 0

摘要

本研究的目的是评估褪黑素替代疗法对松果体切除患者心血管的影响。这是一项前瞻性、开放标签、单臂概念验证研究。该研究包括11例年龄16.7±1.7岁的患者,他们接受了松果体切除术,没有肿瘤复发,且唾液褪黑素水平未检测到。给予6个月的褪黑素治疗方案(每天0.3毫克)。在基线、3个月和6个月的时间间隔进行动态血压监测。首先,松果体切除患者未见高血压。在整个研究过程中,舒张压逐渐下降,在6个月时达到统计学意义。脉压逐渐升高,6个月后达到统计学意义。收缩压和舒张压的短期血压变异性均显著增加。褪黑素替代疗法显著降低了晨间收缩压和舒张压水平。褪黑素对平均心率及其变异性没有影响。褪黑素缺乏的松果体切除患者血压正常。在这些患者中,褪黑素替代导致舒张压降低、脉压升高和短期血压变异性增强。这些结果与心血管健康的改善是一致的。此外,褪黑素的时间特异性表明,它可能会增强夜间恢复,增强清醒时的反应性。虽然褪黑素被用作膳食补充剂具有类似的效果,但建议谨慎使用,并需要进一步研究以优化其在各种健康和疾病背景下的使用。此外,考虑到研究的局限性,更广泛的研究将加强这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human Pinealectomy Syndrome and the Impact of Melatonin Replacement Therapy: 1-Cardiovascular Function

The purpose of this investigational study was to assess the cardiovascular effects of melatonin replacement therapy in pinealectomized patients. This was a prospective open-label, single-arm proof-of-concept study The study comprised 11 patients aged 16.7 ± 1.7 years, who had undergone pinealectomy, experienced no tumor recurrence, and exhibited undetectable salivary melatonin levels. A 6-month melatonin regimen (0.3 mg daily) was administered. Ambulatory blood pressure monitoring was conducted at baseline, 3-month, and 6-month intervals. First of all, no hypertension was observed in pinealectomized patients. Over the course of the study, diastolic blood pressure progressively decreased, reaching statistical significance at 6 months. Pulse pressure exhibited a gradual increase, reaching statistical significance after 6 months. Short-term blood pressure variability increased significantly for both systolic and diastolic pressures. Morning systolic and diastolic blood pressure levels were significantly decreased by melatonin replacement therapy. Melatonin had no effect on the average heart rate or its variability. Melatonin-deficient pinealectomized patients were normotensive. Melatonin replacement in these patients led to reduced diastolic pressure, increased pulse pressure, and enhanced short-term blood pressure variability. These results are consistent with improved cardiovascular health. Furthermore, melatonin's temporal specificity suggests that it might enhance nighttime recovery, heightening reactivity during wakefulness. While melatonin is used as a dietary supplement for similar effects, caution is advised, and further research is needed to optimize its use in various health and disease contexts. Further, considering the study's limitations, more extensive research would strengthen these findings.

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来源期刊
Journal of Pineal Research
Journal of Pineal Research 医学-内分泌学与代谢
CiteScore
17.70
自引率
4.90%
发文量
66
审稿时长
1 months
期刊介绍: The Journal of Pineal Research welcomes original scientific research on the pineal gland and melatonin in vertebrates, as well as the biological functions of melatonin in non-vertebrates, plants, and microorganisms. Criteria for publication include scientific importance, novelty, timeliness, and clarity of presentation. The journal considers experimental data that challenge current thinking and welcomes case reports contributing to understanding the pineal gland and melatonin research. Its aim is to serve researchers in all disciplines related to the pineal gland and melatonin.
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