封面：抗肿瘤药Callistrilone O的全合成在黑色素瘤同种移植小鼠模型中显示出有希望的抗肿瘤活性（ChemMedChem 7/2025）

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-04-01 DOI:10.1002/cmdc.202580701

Kensuke Okuda, Akira Takagi, Ryohei Shimizu, Kensuke Nishi, Narumi Hayano, Ippei Takashima, Morichika Konishi

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引用次数: 0

摘要

完成了强效抗紧缩剂克利斯特酮O的全合成。封面插图描绘了传说中的赫拉克勒斯用他有力的脚踩碎了一只巨蟹，以优先攻击适应营养剥夺的癌症，背景是分离出来的植物Callistemon citrinus。更多细节可以在10.1002/cmdc中找到。202400818，作者：Kensuke Okuda及其同事。封面由Okuda Kensuke教授设计和创作，平面设计师Takashi Tsujino协助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model (ChemMedChem 7/2025)

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Front Cover: Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model (ChemMedChem 7/2025)

Total synthesis of potent antiausterity agent callistrilone O was accomplished. The cover art illustrates that callistrilone O helped the legendary Heracles crushed a giant crab under his mighty foot to preferentially attack cancer that has adapted to nutrient deprivation, with the plant Callistemon citrinus from which it was isolated in the background. More details can be found in article 10.1002/cmdc.202400818 by Kensuke Okuda and co-workers. The cover art was designed and created by Prof. Kensuke Okuda with assistance by graphic designer Takashi Tsujino.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.