{"title":"聚乳酸-羟基乙酸偶联透明质酸给药纳米颗粒的制备、表征及体外评价","authors":"X. Janet Bertilla, S. Rupachandra","doi":"10.1007/s00396-024-05366-4","DOIUrl":null,"url":null,"abstract":"<div><p>A drug delivery formulation is proposed to enhance the therapeutic efficacy of prednisolone while minimizing associated side effects. The method involves making a depolymerized hyaluronic acid conjugated poly(lactic-co-glycolic acid) (dp-HA-<i>g</i>-PLGA) copolymer with a hyaluronan-rich surface that can bind to CD44 receptors. The hydrophobic backbone of PLGA is chemically linked to partially depolymerized hyaluronic acid [dp-HA], augmenting the copolymer’s interaction with CD44 receptors. Prednisolone (PSL)-encapsulated dp-HA-<i>g</i>-PLGA nanoparticles (NPs) were prepared by the single emulsion technique and characterized for key parameters such as size, morphology, drug-loading efficiency, and drug release kinetics study. The average size of the PSL-encapsulated dp-HA-<i>g</i>-PLGA was identified as 271 nm with 74.7% encapsulation efficacy and 6.47% drug-loading efficacy. Furthermore, in vitro assays identify the biocompatibility of the nanoparticles in RAW 264.7 cells. Thus, the findings demonstrate the effectiveness of dp-HA<i>-g</i>-PLGA nanoparticles as a drug carrier for biomedical applications.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"303 4","pages":"669 - 677"},"PeriodicalIF":2.3000,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preparation, characterization and in vitro evaluation of poly[lactic-co-(glycolic acid)] (PLGA) nanoparticles conjugated with depolymerized hyaluronic acid for drug delivery\",\"authors\":\"X. Janet Bertilla, S. Rupachandra\",\"doi\":\"10.1007/s00396-024-05366-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A drug delivery formulation is proposed to enhance the therapeutic efficacy of prednisolone while minimizing associated side effects. The method involves making a depolymerized hyaluronic acid conjugated poly(lactic-co-glycolic acid) (dp-HA-<i>g</i>-PLGA) copolymer with a hyaluronan-rich surface that can bind to CD44 receptors. The hydrophobic backbone of PLGA is chemically linked to partially depolymerized hyaluronic acid [dp-HA], augmenting the copolymer’s interaction with CD44 receptors. Prednisolone (PSL)-encapsulated dp-HA-<i>g</i>-PLGA nanoparticles (NPs) were prepared by the single emulsion technique and characterized for key parameters such as size, morphology, drug-loading efficiency, and drug release kinetics study. The average size of the PSL-encapsulated dp-HA-<i>g</i>-PLGA was identified as 271 nm with 74.7% encapsulation efficacy and 6.47% drug-loading efficacy. Furthermore, in vitro assays identify the biocompatibility of the nanoparticles in RAW 264.7 cells. Thus, the findings demonstrate the effectiveness of dp-HA<i>-g</i>-PLGA nanoparticles as a drug carrier for biomedical applications.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":520,\"journal\":{\"name\":\"Colloid and Polymer Science\",\"volume\":\"303 4\",\"pages\":\"669 - 677\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-01-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloid and Polymer Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00396-024-05366-4\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid and Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00396-024-05366-4","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Preparation, characterization and in vitro evaluation of poly[lactic-co-(glycolic acid)] (PLGA) nanoparticles conjugated with depolymerized hyaluronic acid for drug delivery
A drug delivery formulation is proposed to enhance the therapeutic efficacy of prednisolone while minimizing associated side effects. The method involves making a depolymerized hyaluronic acid conjugated poly(lactic-co-glycolic acid) (dp-HA-g-PLGA) copolymer with a hyaluronan-rich surface that can bind to CD44 receptors. The hydrophobic backbone of PLGA is chemically linked to partially depolymerized hyaluronic acid [dp-HA], augmenting the copolymer’s interaction with CD44 receptors. Prednisolone (PSL)-encapsulated dp-HA-g-PLGA nanoparticles (NPs) were prepared by the single emulsion technique and characterized for key parameters such as size, morphology, drug-loading efficiency, and drug release kinetics study. The average size of the PSL-encapsulated dp-HA-g-PLGA was identified as 271 nm with 74.7% encapsulation efficacy and 6.47% drug-loading efficacy. Furthermore, in vitro assays identify the biocompatibility of the nanoparticles in RAW 264.7 cells. Thus, the findings demonstrate the effectiveness of dp-HA-g-PLGA nanoparticles as a drug carrier for biomedical applications.
期刊介绍：
Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.
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