儿童期社会分裂和感知歧视对临床精神病和健康比较高风险的年轻成人日后生活中适应不良核心图式的作用

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-04-01 DOI:10.1016/j.schres.2025.03.023

Anthony Diomino , Qingyue Yuan , Kristin S. Cadenhead , Jean Addington , Carrie E. Bearden , Tyrone D. Cannon , Matcheri Keshavan , Daniel H. Mathalon , Diana O. Perkins , William S. Stone , Elaine F. Walker , Scott W. Woods , Benson S. Ku

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引用次数: 0

摘要

目的儿童时期的社区社会分裂与未来精神病的发病和较差的社会功能有关。不适应的核心图式可以部分解释这种关系。本研究探讨了儿童时期暴露于区域层面的社会分裂是否与成年后的不适应核心图式相关，以及感知歧视是否在这种关系中起中介作用。方法基线数据收集自北美前驱期纵向研究2（2009-2013）。参与者包括临床精神病高危成人（N = 84）和健康对照（N = 130）。儿童社会分裂来源于1990年和2000年的美国人口普查数据。在基线时评估终生感知歧视和简要核心图式。结果儿童时期社会分裂程度越高，终生感知歧视程度越高（调整后的β = 0.21, 95% CI: 0.03 ~ 0.39），而成年期的积极他人（调整后的β = - 0.21, 95% CI: - 0.35 ~ - 0.07）和消极自我核心图式（调整后的β = 0.36, 95% CI: 0.23 ~ 0.49）的适应不良程度越高。终生感知歧视在童年社会分裂与积极-他人图式的关系中起20.66%的中介作用，在消极-自我图式的关系中起35.96%的中介作用。需要进一步的前瞻性研究来探索跨越发展的社会分裂如何影响核心图式的形成，并为设计干预措施以减轻适应不良的核心图式和精神病理提供潜在的启示。

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The role of childhood social fragmentation and perceived discrimination on maladaptive core schemas later in life among young adults at clinical high risk for psychosis and healthy comparisons

Objective

Neighborhood social fragmentation during childhood has been linked to the future onset of psychosis and poorer social functioning. Maladaptive core schemas may partly explain this relationship. This study examines whether childhood exposure to area-level social fragmentation is associated with maladaptive core schemas in adulthood and whether perceived discrimination mediates this relationship.

Methods

Baseline data were collected from the North American Prodrome Longitudinal Study 2 (2009–2013). Participants included adults at clinical high-risk for psychosis (N = 84) and healthy comparisons (N = 130). Childhood social fragmentation was derived from 1990 and 2000 U.S. Census data. Lifetime perceived discrimination and brief core schemas were assessed at baseline.

Results

Greater childhood social fragmentation was statistically significantly associated with greater lifetime perceived discrimination (adjusted β = 0.21, 95 % CI: 0.03 to 0.39), which was in turn associated with maladaptive positive-other (adjusted β = −0.21, 95 % CI: −0.35 to −0.07) and negative-self core schemas in adulthood (adjusted β = 0.36, 95 % CI: 0.23 to 0.49). Lifetime perceived discrimination mediated 20.66 % of the relationship between childhood social fragmentation and positive-other schemas, and 35.96 % of the relationship with negative-self schemas.

Conclusion

In this cross-sectional study, our findings suggest that growing up in areas with greater social fragmentation may contribute to greater lifetime perceived discrimination, which may be linked to greater maladaptive core schemas in adulthood. Further prospective research is needed to explore how social fragmentation across development may impact core schema formation, with potential implications for designing interventions to mitigate maladaptive core schemas and psychopathology.

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.