aza-Diels-Alder/脱羧反应合成苯胺和酮胺衍生物

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-03-30 DOI:10.1016/j.tetlet.2025.155557

Manli Xu , Tao Han , Xinyan Wu, Rongzheng Tang, Ruiyang Yu, Feng Sha

引用次数: 0

摘要

采用aza-Diels-Alder反应和脱羧反应合成了多种功能化菲咯啶。采用氯胺酮和芳香烃相结合的方法，平稳、高效地构建了菲咯啶核。利用这一方法，实现了天然产物三泼苷和去硝基替丁的快速全合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Phenanthridine derivatives from Arynes and Ketimines via aza-Diels-Alder/decarboxylation reactions

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Synthesis of Phenanthridine derivatives from Arynes and Ketimines via aza-Diels-Alder/decarboxylation reactions

The aza-Diels-Alder and decarboxylation reactions have been developed for the synthesis of a variety of functionalized phenanthridine. The approach by using ketimine and arynes constructed the phenanthridine core smoothly and efficiently. With this strategy, an expeditious total synthesis of the natural products trispheridine and nornitidine has been realized.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.