探索产前邻苯二甲酸盐暴露与新生儿甲状腺功能之间的关系:前瞻性队列研究

IF 11.3 1区 环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL
Zhaoying Xiong, Gaga Mahai, Aizhen Wang, Fasheng Li, Xi Qian, Yizhao Huang, Yuanyuan Li, Wei Xia, Shunqing Xu
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引用次数: 0

摘要

以前的研究报告了产前邻苯二甲酸盐暴露对甲状腺的破坏作用;然而,关于产前邻苯二甲酸盐替代暴露对新生儿甲状腺功能影响的证据仍然有限。基于武汉健康婴儿队列研究的纵向数据,我们旨在调查产前暴露于邻苯二甲酸盐和邻苯二甲酸盐替代品(单独或混合)与新生儿甲状腺功能之间的关系。我们测量了1202名妊娠3个月的母亲尿液样本中邻苯二甲酸酯和邻苯二甲酸酯替代代谢物(mPAEs)的浓度,以及新生儿足跟刺血样本中促甲状腺激素(TSH)的水平。结果表明,某些mPAEs水平较高,特别是邻苯二甲酸一甲酯(MMP)和邻苯二甲酸二甲酯(MECPTP),与新生儿TSH升高有关。mPAEs的四分位数范围(IQR)增加与TSH的增加相关,范围从8.21%到13.5%,并且这种关联更可能发生在女孩身上。分位数g计算模型显示,在妊娠三个月期间,联合暴露于邻苯二甲酸酯与TSH升高显著相关,MEOHP和MMP是最主要的正相关因素。研究结果表明,产前邻苯二甲酸盐暴露可能干扰甲状腺激素稳态,值得进一步验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring the relationships between prenatal phthalate exposure and neonatal thyroid function: A prospective cohort study

Exploring the relationships between prenatal phthalate exposure and neonatal thyroid function: A prospective cohort study
Previous studies have reported the thyroid disruptive effects of prenatal phthalate exposure; however, evidence on the impact of prenatal phthalate alternative exposure on neonatal thyroid function is still limited. We aimed to investigate the associations between prenatal exposure to phthalates and phthalate alternatives (individually and as a mixture) and neonatal thyroid function, based on longitudinal data from the Wuhan Healthy Baby Cohort Study. We measured concentrations of phthalate and phthalate alternative metabolites (mPAEs) in urine samples, provided by 1202 mothers at three trimesters, and neonatal thyroid stimulating hormone (TSH) levels in heel-prick blood samples. The results suggested higher levels of some mPAEs, particularly monomethyl phthalate (MMP) and mono-2-ethyl-5-Carboxypentyl terephthalate (MECPTP), were associated with increased neonatal TSH. Interquartile range (IQR) increases of mPAEs were associated with an increase in TSH ranging from 8.21% to 13.5%, and the associations were more likely to occur in girls. Quantiles g-computation models revealed that joint exposure to phthalates was significantly associated with increased TSH in three trimesters, MEOHP and MMP were the most predominant contributors to the positive associations. The research results imply that prenatal phthalate exposure may interfere with thyroid hormone homeostasis, which warrants further replication.
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来源期刊
Journal of Hazardous Materials
Journal of Hazardous Materials 工程技术-工程:环境
CiteScore
25.40
自引率
5.90%
发文量
3059
审稿时长
58 days
期刊介绍: The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.
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