富硒Kazachstania unispora KU2通过调节肠道菌群和硒蛋白P的合成改善棒霉素诱导的小鼠肠道损伤

IF 11.3 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2025-04-01 DOI:10.1016/j.jhazmat.2025.138129

Furong Wang , Xian Wang , Yilei Xiao , Ruixin Liu , Xiaoben Li , Jinpeng Hu , Wei Song , Kewei Feng , Yahong Yuan , Tianli Yue

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引用次数: 0

摘要

展霉素（PAT）是一种食源性真菌毒素，可引起肠道损伤。富硒Kazachstania unispora (K. unispora) KU2是一种新型饲粮硒载体，硒在肠道内稳态中发挥重要作用。在这里，我们研究了紫杉芽孢菌KU2和富硒紫杉芽孢菌KU2对pat诱导的肠道损伤的改善作用。结果表明，K. unispora KU2和富硒K. unispora KU2均能减轻pat诱导的炎症浸润、肠道微生物群破坏和相关的代谢失衡，表明该菌株具有益生菌潜力。富硒K. KU2比富硒K. KU2具有更明显的修复作用，说明硒的促进作用。此外，富硒K. unispora KU2通过上调SEPP1水平恢复肠道硒稳态，减轻肠道损伤。通过伪无菌小鼠模型，我们证实了肠道微生物群对富硒K. unispora KU2介导的SEPP1合成和肠道运输的改善是必需的。这些发现阐明了一种机制，即富硒K. unispora KU2减轻pat诱导的肠道损伤与肠道微生物群上调SEPP1有关，表明其对肠道疾病的潜在治疗意义。

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Selenium-enriched Kazachstania unispora KU2 ameliorates patulin-induced intestinal injury in mice by mediating the gut microbiota and selenoprotein P synthesis

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Selenium-enriched Kazachstania unispora KU2 ameliorates patulin-induced intestinal injury in mice by mediating the gut microbiota and selenoprotein P synthesis

Patulin (PAT) is a foodborne mycotoxin that causes intestinal injury. Selenium (Se)-enriched Kazachstania unispora (K. unispora) KU2 is a novel dietary Se carrier, and Se exerts important roles in intestinal homeostasis. Here, we examined the ameliorative effects of K. unispora KU2 and Se-enriched K. unispora KU2 against PAT-induced intestinal injury. Results indicated that both K. unispora KU2 and Se-enriched K. unispora KU2 alleviated PAT-induced inflammatory infiltration, disrupted gut microbiota, and associated metabolic imbalances, indicating the probiotic potential of this strain. Se-enriched K. unispora KU2 exhibited more pronounced remediation comparable to K. unispora KU2, revealing the promoting effect of Se. Furthermore, Se-enriched K. unispora KU2 restored intestinal Se homeostasis by upregulating SEPP1 levels to mitigate intestinal injury. Using pseudo germ-free mouse models, we confirmed that gut microbiota was required for the improvement in SEPP1 synthesis and intestinal transport mediated by Se-enriched K. unispora KU2. These findings elucidate a mechanism whereby the alleviation of PAT-induced intestinal injury by Se-enriched K. unispora KU2 is linked to upregulation of SEPP1 by the gut microbiota, suggesting its potential therapeutic relevance for intestinal diseases.

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.