{"title":"植物基因组编辑的未来","authors":"Larry Gilbertson, Holger Puchta, R. Keith Slotkin","doi":"10.1038/s41477-025-01956-4","DOIUrl":null,"url":null,"abstract":"<p>The future of genome editing in plants differs from how it is used today. For both research and product development, we need to think beyond the creation of simple single-nucleotide polymorphisms and short deletions in genes. We believe that the future of genome editing in plants involves mimicking the natural evolutionary processes that have shaped plant genomes and been the target of artificial selection during crop domestication and improvement. This includes programming large structural variations (insertions, duplications, deletions, inversions and translocations) and controlling plant recombination and endogenous transposable elements that naturally reshape plant genomes. The key is that genome editing will be used to reshape plant genomes in a manner that could have happened naturally, but now these changes can be directed rapidly in the laboratory.</p>","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"58 1","pages":""},"PeriodicalIF":15.8000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The future of genome editing in plants\",\"authors\":\"Larry Gilbertson, Holger Puchta, R. Keith Slotkin\",\"doi\":\"10.1038/s41477-025-01956-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The future of genome editing in plants differs from how it is used today. For both research and product development, we need to think beyond the creation of simple single-nucleotide polymorphisms and short deletions in genes. We believe that the future of genome editing in plants involves mimicking the natural evolutionary processes that have shaped plant genomes and been the target of artificial selection during crop domestication and improvement. This includes programming large structural variations (insertions, duplications, deletions, inversions and translocations) and controlling plant recombination and endogenous transposable elements that naturally reshape plant genomes. The key is that genome editing will be used to reshape plant genomes in a manner that could have happened naturally, but now these changes can be directed rapidly in the laboratory.</p>\",\"PeriodicalId\":18904,\"journal\":{\"name\":\"Nature Plants\",\"volume\":\"58 1\",\"pages\":\"\"},\"PeriodicalIF\":15.8000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Plants\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s41477-025-01956-4\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Plants","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41477-025-01956-4","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
The future of genome editing in plants differs from how it is used today. For both research and product development, we need to think beyond the creation of simple single-nucleotide polymorphisms and short deletions in genes. We believe that the future of genome editing in plants involves mimicking the natural evolutionary processes that have shaped plant genomes and been the target of artificial selection during crop domestication and improvement. This includes programming large structural variations (insertions, duplications, deletions, inversions and translocations) and controlling plant recombination and endogenous transposable elements that naturally reshape plant genomes. The key is that genome editing will be used to reshape plant genomes in a manner that could have happened naturally, but now these changes can be directed rapidly in the laboratory.
期刊介绍：
Nature Plants is an online-only, monthly journal publishing the best research on plants — from their evolution, development, metabolism and environmental interactions to their societal significance.
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