从皮肤表面到大脑激活的摩擦性疼痛的体内评估

IF 6.3 1区 工程技术 Q1 ENGINEERING, MECHANICAL
Xingxing Fang, Wei Tang, Yangyang Xia, Shousheng Zhang
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引用次数: 0

摘要

摩擦引起的皮肤疼痛在各种皮肤产品相互作用中很常见。在这项研究中,残肢皮肤与假肢窝之间的相互作用被考虑,以探讨界面摩擦引起皮肤疼痛的潜在机制。系统地研究了主观评价、体内摩擦行为和大脑的神经生理反应。结果表明,摩擦疼痛是摩擦系数与解剖区域和接触材料力学特性共同作用的结果。应根据解剖区域和接触材料的选择来评估摩擦对皮肤疼痛的影响。更强的摩擦刺激可以诱导更高的神经信号被伤害感受器转换,导致t细胞被脊髓背角调节和加工的电位更高。与摩擦性疼痛相关的主要大脑激活发生在初级体感皮层、次级体感皮层和前额叶皮层。摩擦性疼痛诱发大脑负性激活,激活区减小。与无疼痛刺激相比,在轻度或中度疼痛条件下,脑电图信号的γ振荡增加。本研究有助于理解从皮肤表面到大脑反应的摩擦疼痛机制,避免在各种皮肤产品相互作用中进一步损伤皮肤,并为假肢的使用提供理论指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

In vivo assessment of frictional pain from skin surface to brain activation

In vivo assessment of frictional pain from skin surface to brain activation

Skin pain induced by friction is common in various skin-product interactions. In this study, interactions between residual limb skin and prosthetic sockets were taken into account to investigate the underlying mechanism of skin pain induced by interface friction. Subjective evaluation, in vivo tribological behaviors, and neurophysiological responses of the brain were studied systematically. The results demonstrated that frictional pain was subjected to a combination effect of friction coefficient and the mechanical characteristics of anatomic regions and contact materials. The impact of friction on skin pain should be assessed based on the selection of anatomic regions and contact materials. Stronger frictional stimulation can induce higher neural signals to be converted by nociceptors, leading to a higher potential of T-cell to be modulated and processed by the spinal dorsal horn. The main brain activation associated with frictional pain were found in the primary somatosensory cortex, secondary somatosensory cortex, and prefrontal cortex. The brain negative activation was evoked, and the activation area decreased during frictional pain. Compared with no pain stimulation, an increase in γ oscillations of EEG signals was observed in mild or moderate pain conditions. This study is helpful for understanding the mechanisms of frictional pain from the skin surface to brain response and to avoid further skin injury in various skin-product interactions as well as to provide theoretical guidance for the use of prosthetics.

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来源期刊
Friction
Friction Engineering-Mechanical Engineering
CiteScore
12.90
自引率
13.20%
发文量
324
审稿时长
13 weeks
期刊介绍: Friction is a peer-reviewed international journal for the publication of theoretical and experimental research works related to the friction, lubrication and wear. Original, high quality research papers and review articles on all aspects of tribology are welcome, including, but are not limited to, a variety of topics, such as: Friction: Origin of friction, Friction theories, New phenomena of friction, Nano-friction, Ultra-low friction, Molecular friction, Ultra-high friction, Friction at high speed, Friction at high temperature or low temperature, Friction at solid/liquid interfaces, Bio-friction, Adhesion, etc. Lubrication: Superlubricity, Green lubricants, Nano-lubrication, Boundary lubrication, Thin film lubrication, Elastohydrodynamic lubrication, Mixed lubrication, New lubricants, New additives, Gas lubrication, Solid lubrication, etc. Wear: Wear materials, Wear mechanism, Wear models, Wear in severe conditions, Wear measurement, Wear monitoring, etc. Surface Engineering: Surface texturing, Molecular films, Surface coatings, Surface modification, Bionic surfaces, etc. Basic Sciences: Tribology system, Principles of tribology, Thermodynamics of tribo-systems, Micro-fluidics, Thermal stability of tribo-systems, etc. Friction is an open access journal. It is published quarterly by Tsinghua University Press and Springer, and sponsored by the State Key Laboratory of Tribology (TsinghuaUniversity) and the Tribology Institute of Chinese Mechanical Engineering Society.
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