Fcodes更新:具有F-Tree GUI和LLM推理的亲属关系编码框架。

IF 1.5 Q3 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Daniel Pérez-Rodríguez, Roberto C Agís-Balboa, Hugo López-Fernández
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引用次数: 0

摘要

家庭结构在个人发展、社会动态和心理健康方面起着至关重要的作用。编码家谱数据的传统系统,如Ahnentafel和Register System,提供了记录血统的方法,但面临局限性,特别是在适应水平关系或处理家庭数据集的变化方面。像LINKAGE和PED这样的现代计算系统,虽然在基因分析方面功能强大,但缺乏人类的可读性,并且在社会学或精神病学等非结构化、叙述性数据普遍存在的领域应用起来具有挑战性。本文旨在通过增强Fcodes来弥合这一差距,Fcodes是一种灵活而直观的算法,用于编码亲属关系,适合手动和计算使用。在我们之前工作的基础上,我们提出了对Fcodes核心算法和命令行界面(CLI)的改进,以及F-Tree的开发,这是一个新的图形用户界面(GUI),以简化编码过程。此外,我们引入了一种使用Fcodes估计近交系数的方法,并探索了人工智能(即大语言模型(llm))在从叙事文本中自动推断家庭关系方面的应用。这些进步突出了Fcodes在广泛的研究背景下的潜力,从社会研究到遗传学和心理健康研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fcodes update: a kinship encoding framework with F-Tree GUI & LLM inference.

Family structures play a crucial role in personal development, social dynamics, and mental health. Traditional systems for encoding genealogical data, such as Ahnentafel and the Register System, offer methods to document lineage but face limitations, particularly in accommodating horizontal relationships or handling changes in family datasets. Modern computational systems like LINKAGE and PED, while powerful for genetic analysis, lack human readability and are challenging to apply in fields where unstructured, narrative data is common, such as sociology or psychiatry. This paper aims to bridge this gap by enhancing Fcodes, a flexible and intuitive algorithm for encoding kinship relationships that is suited for both manual and computational use. Building on our previous work, we present improvements to the Fcodes core algorithm and command-line interface (CLI), as well as the development of F-Tree, a new graphical user interface (GUI) to streamline the encoding process. Additionally, we introduce a method for estimating the coefficient of inbreeding using Fcodes and explore the application of artificial intelligence, namely large language models (LLMs), to automatically infer family relationships from narrative text. These advancements highlight the potential of Fcodes in a wide range of research contexts, from social studies to genetics and mental health research.

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来源期刊
Journal of Integrative Bioinformatics
Journal of Integrative Bioinformatics Medicine-Medicine (all)
CiteScore
3.10
自引率
5.30%
发文量
27
审稿时长
12 weeks
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