解读抗体免疫压力下SARS-CoV-2的进化

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI:10.1016/j.it.2025.03.002

Fanchong Jian, Yunlong Cao

引用次数: 0

摘要

SARS-CoV-2的持续进化通过免疫逃逸突变对现有的中和抗体和疫苗提出了重大挑战。通过利用基因组监测和抗体深度突变扫描（DMS）数据，Raharinirina及其同事开发了一个计算框架，以阐明区域特异性SARS-CoV-2变异动态，并预测群体免疫下的进化趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Deciphering SARS-CoV-2 evolution under antibody immune pressure.

The ongoing evolution of SARS-CoV-2 poses significant challenges to existing neutralizing antibodies and vaccines through immune escape mutations. By leveraging genomic surveillance and antibody deep mutational scanning (DMS) data, Raharinirina and colleagues developed a computational framework to elucidate region-specific SARS-CoV-2 variant dynamics and predict evolutionary trends under population immunity.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.