Eru Mba, Gabriel U Udo-Affah, I F Bassey, K C Uruakpa, S O Paulinus, M E Oku, N M Umoh, S E Anani, A O Agiri
{"title":"三角taltalum水提物对氢溴酸东莨菪碱诱导的阿尔茨海默型认知功能障碍大鼠海马微观解剖及短期记忆的影响。","authors":"Eru Mba, Gabriel U Udo-Affah, I F Bassey, K C Uruakpa, S O Paulinus, M E Oku, N M Umoh, S E Anani, A O Agiri","doi":"10.54548/njps.v39i1.13","DOIUrl":null,"url":null,"abstract":"<p><p>The study aimed at elucidating the potency of aqueous extract of Talinum triangulare on the hippocampal neurons, astrocytes as well as assessing short term memory of scopolamine-induced Alzheimer's type rats. Fifty-four Wistar rats (180-200g) were used for the study; thirty experimental rats were randomly grouped into five, each containing six rats designated A, B, C, D and E while twenty-four rats were used to establish 50% lethal dose (LD50). Alzheimer's type cognitive dysfunction was intraperitoneally (ip) induced with scopolamine hydrobromide (1mg/kg, ip) for seven days in groups B-E prior to the oral administration of the aqueous extract (875 and 1750mg/kg) and donepezil (1mg/kg), followed by the novel object recognition test, histological and GFAP staining processes. Results revealed atrophied pyramidal cells, hyperchromatic, numerous glial cells with pale cytoplasmic inclusions and astrogliosis in groups B, C, and E while group D showed ameliorative potentials compared to group A. Also, short term memory was significantly higher in group D compared to groups B, C and E. In conclusion, aqueous extract of Talinium triangulare leaves reduced the potentials of scopolamine hydrobromide by restoring abnormal neurons, hence, enhancing cognitive memory in the rats used in the present study.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"39 1","pages":"101-109"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy of Aqueous Extract of Talinum Triangulare on the Microanatomy of the Hippocampus and Short-Term Memory of Scopolamine Hydrobromide-Induced Alzheimer's Type Cognitive Dysfunction Rats.\",\"authors\":\"Eru Mba, Gabriel U Udo-Affah, I F Bassey, K C Uruakpa, S O Paulinus, M E Oku, N M Umoh, S E Anani, A O Agiri\",\"doi\":\"10.54548/njps.v39i1.13\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The study aimed at elucidating the potency of aqueous extract of Talinum triangulare on the hippocampal neurons, astrocytes as well as assessing short term memory of scopolamine-induced Alzheimer's type rats. Fifty-four Wistar rats (180-200g) were used for the study; thirty experimental rats were randomly grouped into five, each containing six rats designated A, B, C, D and E while twenty-four rats were used to establish 50% lethal dose (LD50). Alzheimer's type cognitive dysfunction was intraperitoneally (ip) induced with scopolamine hydrobromide (1mg/kg, ip) for seven days in groups B-E prior to the oral administration of the aqueous extract (875 and 1750mg/kg) and donepezil (1mg/kg), followed by the novel object recognition test, histological and GFAP staining processes. Results revealed atrophied pyramidal cells, hyperchromatic, numerous glial cells with pale cytoplasmic inclusions and astrogliosis in groups B, C, and E while group D showed ameliorative potentials compared to group A. Also, short term memory was significantly higher in group D compared to groups B, C and E. In conclusion, aqueous extract of Talinium triangulare leaves reduced the potentials of scopolamine hydrobromide by restoring abnormal neurons, hence, enhancing cognitive memory in the rats used in the present study.</p>\",\"PeriodicalId\":35043,\"journal\":{\"name\":\"Nigerian Journal of Physiological Sciences\",\"volume\":\"39 1\",\"pages\":\"101-109\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian Journal of Physiological Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54548/njps.v39i1.13\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Physiological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54548/njps.v39i1.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Efficacy of Aqueous Extract of Talinum Triangulare on the Microanatomy of the Hippocampus and Short-Term Memory of Scopolamine Hydrobromide-Induced Alzheimer's Type Cognitive Dysfunction Rats.
The study aimed at elucidating the potency of aqueous extract of Talinum triangulare on the hippocampal neurons, astrocytes as well as assessing short term memory of scopolamine-induced Alzheimer's type rats. Fifty-four Wistar rats (180-200g) were used for the study; thirty experimental rats were randomly grouped into five, each containing six rats designated A, B, C, D and E while twenty-four rats were used to establish 50% lethal dose (LD50). Alzheimer's type cognitive dysfunction was intraperitoneally (ip) induced with scopolamine hydrobromide (1mg/kg, ip) for seven days in groups B-E prior to the oral administration of the aqueous extract (875 and 1750mg/kg) and donepezil (1mg/kg), followed by the novel object recognition test, histological and GFAP staining processes. Results revealed atrophied pyramidal cells, hyperchromatic, numerous glial cells with pale cytoplasmic inclusions and astrogliosis in groups B, C, and E while group D showed ameliorative potentials compared to group A. Also, short term memory was significantly higher in group D compared to groups B, C and E. In conclusion, aqueous extract of Talinium triangulare leaves reduced the potentials of scopolamine hydrobromide by restoring abnormal neurons, hence, enhancing cognitive memory in the rats used in the present study.