调节非编码rna的天然产物抗肿瘤治疗的机制和潜力。

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Zhuguo Wang, Fei Wang, Huiming Huang, Xinyu Qiu, Peng Tan, Xuejiao Wei, Ruoxin Zhang, Yufeng Gao, Zhongdong Hu
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引用次数: 0

摘要

非编码RNA (Non-coding RNAs, ncRNAs)是一类独特的RNA转录物,因其在肿瘤恶性过程中复杂而重要的作用而受到全球科学界的广泛关注。ncRNAs的表达失调与不同类型癌症的进展密切相关,这表明ncRNAs是关键的调节因子,可以调节许多癌症生物标志物。包括微rna (miRNAs)、长链非编码rna (lncRNAs)和环状rna (circRNAs)在内的调节性ncRNAs之间的复杂相互作用,以及它们与mrna或rna结合蛋白的复杂相互作用,在肿瘤中协调了许多生物学过程。从饮食或药物来源获得的天然产品非常安全,并且具有稳定的治疗效果。这些产物可以调控ncrna,有效抑制肿瘤细胞生长和增殖,甚至引发细胞死亡。这种能力强调了它们可以减轻肿瘤负担,提高癌症患者的临床疗效。在这篇综述中,我们讨论了ncRNAs介导的肿瘤调控的复杂机制,并系统地强调了特异性控制ncRNAs的天然产物的多种抗肿瘤应用。我们的目标是在抗癌研究领域提供新的视角和方法,重点是天然产物的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanisms and Potential of Antitumor Therapy With Natural Products Regulating Non-Coding RNAs.

Non-coding RNAs (ncRNAs) are a distinctive class of RNA transcripts that have received extensive attention from the global scientific community due to their intricate and important roles in tumor malignancy. The dysregulated expression of ncRNAs is closely associated with the progression of different types of cancer, suggesting that ncRNAs serve as key regulatory factors and modulate numerous cancer biomarkers. The complex interactions between regulatory ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), as well as their intricate interactions with mRNAs or RNA-binding proteins, orchestrate many biological processes in tumors. Natural products, obtained from dietary or medicinal sources, are extremely safe and have stable therapeutic outcomes. These products can regulate ncRNAs, effectively inhibiting tumor cell growth and proliferation and even triggering cell death. This ability highlights that they can reduce tumor burden and enhance clinical outcomes for cancer patients. In this review we discussed the intricate mechanisms underlying ncRNAs-mediated tumor regulation and systematically highlighted the diverse antitumor applications of natural products that specifically control regulatory ncRNAs. We aimed to provide novel perspectives and methods in the field of anticancer research, focusing on the application of natural products.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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