生理衰老轨迹的性别和教育差异:一项前瞻性英语队列研究的纵向分析。

IF 6 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Mikaela Bloomberg, Andrew Steptoe
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引用次数: 0

摘要

背景:生理年龄(PA)来源于临床指标,包括基于血液的生物标志物和生理功能测试,可以与实足年龄进行比较,以检查相同年龄的老年人之间的健康差异。虽然教育与性别相互作用导致健康老龄化的不平等,但它们对纵向测量的PA的综合影响尚未得到探讨。我们根据纵向测量的临床指标推导出了PA,并研究了性别和教育如何相互作用以告知PA轨迹。方法:采用来自英国老龄化纵向研究(50-100岁)的三波临床指标(2004/05-2012/13)来估计PA,并通过确认在调整实足年龄和性别后与偶发慢性疾病、功能限制和记忆障碍的关联进行内部验证。在8891名英国老龄化纵向研究参与者中,采用联合模型构建了养老保险的轨迹,以检验养老保险的性别和教育差异。研究结果:在受教育程度最低的参与者中,直到60岁为止,性别差异可以忽略不计(50岁时性别差异[男性-女性]= -0.6岁[95%置信区间= -2.2至0.6];60岁= 0.4 [-0.6 ~ 1.4]);在70岁时,女性比男性年长1.5岁(0.7-2.2岁)。在受教育程度最高的参与者中,女性在50岁时比男性年轻3.8岁(1.6-6.0岁),在60岁时比男性年轻2.7岁(0.4-5.0岁),在70岁时性别差异不显著。解释:与男性相比,高等教育为女性生理衰老提供了更大的中年缓冲。促进高等教育性别平等的政策可能有助于在一系列与老龄化有关的成果方面改善妇女的健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex and education differences in trajectories of physiological ageing: longitudinal analysis of a prospective English cohort study.

Background: Physiological age (PA) derived from clinical indicators including blood-based biomarkers and tests of physiological function can be compared with chronological age to examine disparities in health between older adults of the same age. Though education interacts with sex to lead to inequalities in healthy ageing, their combined influence on longitudinally measured PA has not been explored. We derived PA based on longitudinally measured clinical indicators and examined how sex and education interact to inform PA trajectories.

Methods: Three waves of clinical indicators (2004/05-2012/13) drawn from the English Longitudinal Study of Ageing (ages 50-100 years) were used to estimate PA, which was internally validated by confirming associations with incident chronic conditions, functional limitations and memory impairment after adjustment for chronological age and sex. Joint models were used to construct PA trajectories in 8891 English Longitudinal Study of Ageing participants to examine sex and educational disparities in PA.

Findings: Amongst the least educated participants, there were negligible sex differences in PA until age 60 (sex difference [men-women] age 50 = -0.6 years [95% confidence interval = -2.2 to 0.6]; age 60 = 0.4 [-0.6 to 1.4]); at age 70, women were 1.5 years (0.7-2.2) older than men. Amongst the most educated participants, women were 3.8 years (1.6-6.0) younger than men at age 50 and 2.7 years (0.4-5.0) younger at age 60, with a nonsignificant sex difference at age 70.

Interpretation: Higher education provides a larger midlife buffer to physiological ageing for women than men. Policies to promote gender equity in higher education may contribute to improving women's health across a range of ageing-related outcomes.

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来源期刊
Age and ageing
Age and ageing 医学-老年医学
CiteScore
9.20
自引率
6.00%
发文量
796
审稿时长
4-8 weeks
期刊介绍: Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.
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