封面：利用ROS收获Ir(III)-环金属化咪唑邻菲罗啉配合物对MDA-MB-231细胞诱导可见光激发的DNA损伤j . Inorg。化学10/2025)

IF 2.2 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

European Journal of Inorganic Chemistry Pub Date : 2025-04-01 DOI:10.1002/ejic.202581001

Sreejani Ghosh, Priyankar Paira

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引用次数: 0

摘要

封面展示了基于咪唑菲罗啉的铱（III）环金属化配合物，能够通过II型和II型PDT途径产生ROS，以响应光暴露；这会导致DNA损伤，从而最终消灭MDA-MB-231 TNBC细胞。这些复合物具有显著的光稳定性，使它们能够承受可见光。此外，这些复合物可以氧化NADH和谷胱甘肽，从而引发癌细胞的氧化应激。更多信息可以在S. Ghosh和P. Paira的研究文章中找到（DOI: 10.1002/ejic.202400769）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Instigating Visible Light Inspired DNA Impairment by ROS Harvesting Ir(III)-Cyclometallated Imidazophenanthroline Complexes Against MDA-MB-231 Cells (Eur. J. Inorg. Chem. 10/2025)

查看原文本刊更多论文

Front Cover: Instigating Visible Light Inspired DNA Impairment by ROS Harvesting Ir(III)-Cyclometallated Imidazophenanthroline Complexes Against MDA-MB-231 Cells (Eur. J. Inorg. Chem. 10/2025)

The Front Cover demonstrates imidazophenanthroline-based iridium(III) cyclometallated complexes that are capable of generating ROS via type II and type II PDT pathways in response to light exposure; this induces DNA damage and thus, ultimately annihilates MDA-MB-231 TNBC cells. The complexes have remarkable photostability that allows them to withstand visible light. Furthermore, the complexes can oxidize NADH and GSH, which triggers oxidative stress in cancer cells. More information can be found in the Research Article by S. Ghosh and P. Paira (DOI: 10.1002/ejic.202400769).

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来源期刊

European Journal of Inorganic Chemistry 化学-无机化学与核化学

CiteScore

4.30

自引率

4.30%

发文量

419

审稿时长

1.3 months

期刊介绍： The European Journal of Inorganic Chemistry (2019 ISI Impact Factor: 2.529) publishes Full Papers, Communications, and Minireviews from the entire spectrum of inorganic, organometallic, bioinorganic, and solid-state chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form the two leading journals, European Journal of Inorganic Chemistry and European Journal of Organic Chemistry: Chemische Berichte Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry The European Journal of Inorganic Chemistry continues to keep you up-to-date with important inorganic chemistry research results.