一氧化氮清除胶束通过Th2细胞因子调节减轻哮喘气道炎症

IF 5.2 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Advances Pub Date : 2025-03-18 DOI:10.1039/D4MA01135J

Daoxiang Rong, Shanshan Fang, Shaohu Huo, Paiyu Lin, Jian Cheng, Jingfang Hong and Shenggang Ding

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引用次数: 0

摘要

过敏性哮喘是一种慢性炎症性气道疾病。一氧化氮（NO）是这种炎症的关键分子，在哮喘中升高，导致控制不良和症状恶化。在本研究中，我们开发了一氧化氮清除胶束（NOSMs）来降低过敏小鼠模型中的一氧化氮浓度并减轻肺部炎症。NOSMs有效降低气道NO水平，显著抑制促炎因子IL-6和IL-13的产生，促进IFN-γ的释放。因此，NOSMs可能通过清除NO和调节th2相关的肺部炎症在治疗过敏性哮喘中发挥关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nitric oxide-scavenging micelles alleviate airway inflammation in asthma via Th2 cytokine modulation†

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Nitric oxide-scavenging micelles alleviate airway inflammation in asthma via Th2 cytokine modulation†

Allergic asthma is a chronic inflammatory airway disease. Nitric oxide (NO), a key molecule in this inflammation, is elevated in asthma and contributes to poor control and worsened symptoms. In this study, we developed nitric oxide-scavenging micelles (NOSMs) to reduce NO concentration and alleviate pulmonary inflammation in an allergic mouse model. NOSMs effectively lower airway NO levels, significantly inhibit the production of pro-inflammatory factors IL-6 and IL-13, and promote the release of IFN-γ. Thus, NOSMs may play a key role in treating allergic asthma by scavenging NO and modulating Th2-related pulmonary inflammation.

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