R. Sánchez Martín , A. Miranda , J. Monserrat Sanz , M. Álvarez-Mon
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引用次数: 0
摘要
B 淋巴细胞是适应性免疫的基础。它们在抗体产生和免疫记忆形成中发挥着关键作用。它们的发育始于原发性淋巴器官，在那里进行基因的体细胞重组以形成 B 细胞受体。在继发性淋巴器官中，B 淋巴细胞以依赖胸腺或不依赖胸腺的方式对抗原做出反应。B 淋巴细胞的异常会导致自身免疫性疾病、过敏症和淋巴瘤。单克隆抗体和细胞疗法等创新疗法为治疗血液肿瘤和自身免疫性疾病提供了新的选择。本文旨在以简单的方式回顾和更新 B 淋巴细胞的分化、功能和类别的基本原理，并探讨治疗 B 淋巴细胞相关疾病的治疗进展。
Diferenciación, activación y clasificación de los linfocitos B
B lymphocytes are fundamental to adaptive immunity. They play a key role in antibody production and immune memory formation. Their development begins in primary lymphoid organs, where processes such as somatic recombination of genes to form the B cell receptor take place. In secondary lymphoid organs, B lymphocytes respond to the antigen in a thymus-dependent or thymus-independent manner. Abnormalities in B lymphocytes contribute to autoimmune diseases, hypersensitivities, and lymphomas. Innovative therapies, such as monoclonal antibodies and cellular approaches, offer new options for treating hematologic cancers and autoimmune diseases.
This article aims to review and update in a simple manner the fundamentals of the differentiation, functions, and classes of B lymphocytes as well as to explore therapeutic advances in the treatment of diseases in which B lymphocytes are involved.
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