在棉织物上设计具有不同形态的聚（2-乙基-2-恶唑啉）和水性聚氨酯的静电纺纳米纤维：抗菌活性及其与SARS-CoV-2相互作用的多功能方法

IF 5.8 2区化学 Q1 POLYMER SCIENCE

European Polymer Journal Pub Date : 2025-03-27 DOI:10.1016/j.eurpolymj.2025.113907

Burhan Beycan , Meryem Kalkan Erdoğan , Merve Eylul Kiymaci , Nilgün Ünal , Sevcan Yangın , Begum Yurdakok – Dikmen , Ayhan Filazi , Meral Karakışla , Mehmet Saçak

{"title":"在棉织物上设计具有不同形态的聚（2-乙基-2-恶唑啉）和水性聚氨酯的静电纺纳米纤维：抗菌活性及其与SARS-CoV-2相互作用的多功能方法","authors":"Burhan Beycan , Meryem Kalkan Erdoğan , Merve Eylul Kiymaci , Nilgün Ünal , Sevcan Yangın , Begum Yurdakok – Dikmen , Ayhan Filazi , Meral Karakışla , Mehmet Saçak","doi":"10.1016/j.eurpolymj.2025.113907","DOIUrl":null,"url":null,"abstract":"<div><div>This study introduces the development of reusable and antimicrobial face mask materials by coating cotton fabric surfaces with electrospun nanofibrous meshes. A waterborne polyurethane (WBPU) polymer, synthesized from biodegradable sources under mild, catalyst-free conditions, served as the primary coating material. The WBPU polymer was combined with poly(2-ethyl-2-oxazoline) (P2Ox), a biocompatible polymer, and its hydrolyzed derivative, poly(2-ethyl-2-oxazoline)-co-poly(ethylene imine) (P2Ox-co-PEI). These polymer blends were electrospun onto cotton fabrics to form nanofibrous meshes in three distinct morphologies: hybrid, Janus, and core–shell. The materials were characterized using comprehensive techniques, including optical and scanning electron microscopy (SEM), mechanical testing (breaking force and elongation), air permeability measurements, and water contact angle-wetting time assessments. The results revealed enhanced material properties, including improved mechanical strength, optimized wettability, and adequate air permeability suitable for protective face masks. Biocompatibility was demonstrated through cell proliferation tests using mouse fibroblasts, showing a 30 % increase in cell growth on the coated fabrics. Antimicrobial efficacy was assessed against <em>Staphylococcus aureus</em> (<em>S. aureus</em>) ATCC 29213 and <em>Candida albicans</em> (<em>C.albicans</em>) ATCC 10231 (100 % inhibition) and antiviral activity against COVID-19 virus SARS-CoV-2 (94.11 % reduction), highlighting the potential for these materials as alternatives to conventional surgical masks. This work underscores the feasibility of creating sustainable, high-performance protective fabrics that combine biodegradability, biocompatibility, and robust antimicrobial properties, offering a promising solution for personal protective equipment in medical and non-medical applications.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"231 ","pages":"Article 113907"},"PeriodicalIF":5.8000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Designing electrospun nanofibers in the distinct morphologies from poly(2-ethyl-2-oxazoline) and waterborne polyurethane on the cotton fabric: A multifunctional approach for antimicrobial activity and its interaction with SARS-CoV-2\",\"authors\":\"Burhan Beycan , Meryem Kalkan Erdoğan , Merve Eylul Kiymaci , Nilgün Ünal , Sevcan Yangın , Begum Yurdakok – Dikmen , Ayhan Filazi , Meral Karakışla , Mehmet Saçak\",\"doi\":\"10.1016/j.eurpolymj.2025.113907\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study introduces the development of reusable and antimicrobial face mask materials by coating cotton fabric surfaces with electrospun nanofibrous meshes. A waterborne polyurethane (WBPU) polymer, synthesized from biodegradable sources under mild, catalyst-free conditions, served as the primary coating material. The WBPU polymer was combined with poly(2-ethyl-2-oxazoline) (P2Ox), a biocompatible polymer, and its hydrolyzed derivative, poly(2-ethyl-2-oxazoline)-co-poly(ethylene imine) (P2Ox-co-PEI). These polymer blends were electrospun onto cotton fabrics to form nanofibrous meshes in three distinct morphologies: hybrid, Janus, and core–shell. The materials were characterized using comprehensive techniques, including optical and scanning electron microscopy (SEM), mechanical testing (breaking force and elongation), air permeability measurements, and water contact angle-wetting time assessments. The results revealed enhanced material properties, including improved mechanical strength, optimized wettability, and adequate air permeability suitable for protective face masks. Biocompatibility was demonstrated through cell proliferation tests using mouse fibroblasts, showing a 30 % increase in cell growth on the coated fabrics. Antimicrobial efficacy was assessed against <em>Staphylococcus aureus</em> (<em>S. aureus</em>) ATCC 29213 and <em>Candida albicans</em> (<em>C.albicans</em>) ATCC 10231 (100 % inhibition) and antiviral activity against COVID-19 virus SARS-CoV-2 (94.11 % reduction), highlighting the potential for these materials as alternatives to conventional surgical masks. This work underscores the feasibility of creating sustainable, high-performance protective fabrics that combine biodegradability, biocompatibility, and robust antimicrobial properties, offering a promising solution for personal protective equipment in medical and non-medical applications.</div></div>\",\"PeriodicalId\":315,\"journal\":{\"name\":\"European Polymer Journal\",\"volume\":\"231 \",\"pages\":\"Article 113907\"},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2025-03-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Polymer Journal\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014305725001958\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Polymer Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014305725001958","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}

引用次数: 0

摘要

本研究介绍了在棉织物表面涂覆电纺纳米纤维网的可重复使用和抗菌口罩材料的开发。水性聚氨酯（WBPU）聚合物是在温和、无催化剂的条件下由可生物降解的原料合成的，作为主要的涂层材料。WBPU聚合物与生物相容性聚合物聚（2-乙基-2-恶唑啉）（p2o）及其水解衍生物聚（2-乙基-2-恶唑啉）-共聚乙烯亚胺（p2o -co- pei）结合。这些聚合物共混物被电纺丝到棉织物上，形成三种不同形态的纳米纤维网：混合、双面和核壳。使用综合技术对材料进行了表征，包括光学和扫描电子显微镜（SEM），力学测试（断裂力和伸长率），透气性测量和水接触角-润湿时间评估。结果显示增强的材料性能，包括改进的机械强度，优化的润湿性和足够的透气性，适合防护口罩。生物相容性通过小鼠成纤维细胞的细胞增殖试验得到证实，表明涂层织物上的细胞生长增加了30%。对金黄色葡萄球菌（S. aureus） ATCC 29213和白色念珠菌（C.albicans） ATCC 10231的抗菌效果进行了评估（100%抑制），并对COVID-19病毒SARS-CoV-2的抗病毒活性进行了评估（降低94.11%），突出了这些材料作为传统外科口罩替代品的潜力。这项工作强调了创造可持续的高性能防护织物的可行性，这种织物结合了生物可降解性、生物相容性和强大的抗菌性能，为医疗和非医疗应用中的个人防护设备提供了一个有前途的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Designing electrospun nanofibers in the distinct morphologies from poly(2-ethyl-2-oxazoline) and waterborne polyurethane on the cotton fabric: A multifunctional approach for antimicrobial activity and its interaction with SARS-CoV-2

查看原文本刊更多论文

This study introduces the development of reusable and antimicrobial face mask materials by coating cotton fabric surfaces with electrospun nanofibrous meshes. A waterborne polyurethane (WBPU) polymer, synthesized from biodegradable sources under mild, catalyst-free conditions, served as the primary coating material. The WBPU polymer was combined with poly(2-ethyl-2-oxazoline) (P2Ox), a biocompatible polymer, and its hydrolyzed derivative, poly(2-ethyl-2-oxazoline)-co-poly(ethylene imine) (P2Ox-co-PEI). These polymer blends were electrospun onto cotton fabrics to form nanofibrous meshes in three distinct morphologies: hybrid, Janus, and core–shell. The materials were characterized using comprehensive techniques, including optical and scanning electron microscopy (SEM), mechanical testing (breaking force and elongation), air permeability measurements, and water contact angle-wetting time assessments. The results revealed enhanced material properties, including improved mechanical strength, optimized wettability, and adequate air permeability suitable for protective face masks. Biocompatibility was demonstrated through cell proliferation tests using mouse fibroblasts, showing a 30 % increase in cell growth on the coated fabrics. Antimicrobial efficacy was assessed against Staphylococcus aureus (S. aureus) ATCC 29213 and Candida albicans (C.albicans) ATCC 10231 (100 % inhibition) and antiviral activity against COVID-19 virus SARS-CoV-2 (94.11 % reduction), highlighting the potential for these materials as alternatives to conventional surgical masks. This work underscores the feasibility of creating sustainable, high-performance protective fabrics that combine biodegradability, biocompatibility, and robust antimicrobial properties, offering a promising solution for personal protective equipment in medical and non-medical applications.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

European Polymer Journal 化学-高分子科学

CiteScore

9.90

自引率

10.00%

发文量

691

审稿时长

23 days

期刊介绍： European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.