烯烃与亚硫酸盐的无催化剂和无溶剂的氢磺化反应，使β-磺酰酰胺的绿色合成成为可能

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-28 DOI:10.1016/j.tet.2025.134632

Dan Luo, Qian Wang, Haibo Mei, Jianlin Han

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引用次数: 0

摘要

研究了以亚硫酸钠为Michael给体的烯烃氢磺酰化反应，得到收率高达99%的β-磺酰酰胺产品。该反应在温和的条件下进行，不需要任何催化剂，特别是不需要溶剂。这个反应是在整洁条件下与亚硫酸钠的氢磺酰化反应的第一个例子。此外，该反应具有结构多样的烯烃和亚硫酸钠的广泛特性，为合成β-磺酰酰胺提供了一种绿色而有价值的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Catalyst- and solvent-free hydrosulfonylation of alkenes with sulfinates enabling green synthesis of β-sulfonyl amides

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Catalyst- and solvent-free hydrosulfonylation of alkenes with sulfinates enabling green synthesis of β-sulfonyl amides

An efficient hydrosulfonylation reaction of alkenes with sodium sulfinates as Michael donors has been developed, which affords β-sulfonyl amides as products with up to 99 % yield. This reaction was conducted under mild conditions without the need of any catalyst, in particular, no solvent was needed for this transformation. This reaction represents the first example of hydrosulfonylation reaction with sodium sulfinates under neat conditions. Moreover, this reaction features wide range of structurally diverse alkenes and sodium sulfinates, which provides a green and valuable strategy for the synthesis of β-sulfonyl amides.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.