沙特阿拉伯一项为期11年的丙型肝炎回顾性研究：血清转化、恢复率和病毒基因型分布

IF 2.8 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-03-21 DOI:10.1016/j.virol.2025.110505

Adnan A. Mubaraki , Mohammed A. Alabdalli , Ahmed K. Shawush , Muhanna A. Alhusayni , Abdullah A. Hammadi , Awatief A. Edries , Daifallah Alaboud , Ahmed S. Abdel-Moneim

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引用次数: 0

摘要

丙型肝炎病毒（HCV）感染仍然是一个全球卫生问题。该研究分析了2011年至2022年期间来自沙特阿拉伯患者的95,864份血浆样本，以检查HCV血清转化、病毒载量和基因型分布。采用ARCHITECT抗HCV试验进行血清学筛选，采用实时RT-PCR定量HCV RNA水平。在970例hcv阳性病例中，47.9%的患者自发康复，而52.1%的患者持续感染。年血清阳性率从2011年的2.05%显著下降到2022年的0.34%。107份持续感染样本的基因分型显示基因4型（49.5%）和1a型（17.8%）最为常见，其他基因型出现的频率较低。此外，13份（12.1%）样品具有无法分型的基因型。该研究强调了HCV感染率的下降，自发恢复率高，以及基因型4和1a的优势。持续监测和基因分型，包括无法分型的病例，对沙特阿拉伯有效管理丙肝病毒至关重要。

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An 11-year retrospective study on hepatitis C in Saudi Arabia: Seroconversion, recovery rates, and viral genotype distribution

Hepatitis C virus (HCV) infection remains a global health concern. This study analyzed 95,864 plasma samples from Saudi patients between 2011 and 2022 to examine HCV seroconversion, viral load, and genotype distribution. Serological screening was performed using the ARCHITECT anti-HCV assay, and HCV RNA levels were quantified with real-time RT-PCR. Of the 970 HCV-positive cases, 47.9 % experienced spontaneous recovery, while 52.1 % had persistent infection. The annual seropositivity rate declined significantly from 2.05 % in 2011 to 0.34 % in 2022. Genotyping of 107 persistently infected samples showed genotypes 4 (49.5 %) and 1a (17.8 %) as the most common, with other genotypes appearing less frequently. Additionally, 13 (12.1 %) samples had untypable genotypes. This study highlights the decrease in HCV infection rates, the high rate of spontaneous recovery, and the predominance of genotypes 4 and 1a. Ongoing surveillance and genotyping, including untypable cases, are essential for effective HCV management in Saudi Arabia.

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.