基于核磁共振的代谢组学揭示了四羟基二苯乙烯苷对抗d -半乳糖诱导的大鼠衰老的潜在机制

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-04-01 DOI:10.1016/j.phytol.2025.102955

Minghui Li , Hui Chai , Tianxiang Chao , Jianye Huang , Limin Han , Qingwang Liu , Lu Yang

{"title":"基于核磁共振的代谢组学揭示了四羟基二苯乙烯苷对抗d -半乳糖诱导的大鼠衰老的潜在机制","authors":"Minghui Li , Hui Chai , Tianxiang Chao , Jianye Huang , Limin Han , Qingwang Liu , Lu Yang","doi":"10.1016/j.phytol.2025.102955","DOIUrl":null,"url":null,"abstract":"<div><div>Aging represents a significant threat to human health, underscoring the critical need for effective anti-aging interventions. In this study, we utilized a comprehensive approach combining ¹H NMR-based metabolomics, serum biochemical analysis, and liver histopathology to evaluate the protective effects of tetrahydroxy stilbene glycoside (TSG) on D-galactose-induced aging in rats. Our findings demonstrate that TSG significantly enhances antioxidant activity and alleviates D-galactose-induced liver damage. Metabolomic analysis revealed increased levels in 3-hydroxybutyrate, succinate, and tryptophan, alongside decreased levels in alanine, arginine, and acetate, in the serum of aging rats. TSG treatment effectively reversed these metabolic perturbations. Further pathway analysis indicated that TSG restored balance in several key metabolic pathways, such as phenylalanine and tyrosine metabolism, betaine metabolism, carnitine synthesis, and methionine metabolism. In summary, TSG not only bolstered antioxidant defenses and alleviated liver injury but also normalized metabolic dysregulation in aging rats. These findings highlight TSG's potential as a promising anti-aging agent and support its further exploration for clinical applications.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"67 ","pages":"Article 102955"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NMR-based metabolomics unveils the potential mechanism of tetrahydroxy stilbene glycoside in combating D-galactose-induced aging in rats\",\"authors\":\"Minghui Li , Hui Chai , Tianxiang Chao , Jianye Huang , Limin Han , Qingwang Liu , Lu Yang\",\"doi\":\"10.1016/j.phytol.2025.102955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Aging represents a significant threat to human health, underscoring the critical need for effective anti-aging interventions. In this study, we utilized a comprehensive approach combining ¹H NMR-based metabolomics, serum biochemical analysis, and liver histopathology to evaluate the protective effects of tetrahydroxy stilbene glycoside (TSG) on D-galactose-induced aging in rats. Our findings demonstrate that TSG significantly enhances antioxidant activity and alleviates D-galactose-induced liver damage. Metabolomic analysis revealed increased levels in 3-hydroxybutyrate, succinate, and tryptophan, alongside decreased levels in alanine, arginine, and acetate, in the serum of aging rats. TSG treatment effectively reversed these metabolic perturbations. Further pathway analysis indicated that TSG restored balance in several key metabolic pathways, such as phenylalanine and tyrosine metabolism, betaine metabolism, carnitine synthesis, and methionine metabolism. In summary, TSG not only bolstered antioxidant defenses and alleviated liver injury but also normalized metabolic dysregulation in aging rats. These findings highlight TSG's potential as a promising anti-aging agent and support its further exploration for clinical applications.</div></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"67 \",\"pages\":\"Article 102955\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390025010444\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390025010444","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

老龄化对人类健康构成重大威胁，因此迫切需要采取有效的抗衰老干预措施。本研究采用基于H核磁共振的代谢组学、血清生化分析和肝脏组织病理学相结合的综合方法来评估四羟基二苯乙烯苷（TSG）对d -半乳糖诱导的大鼠衰老的保护作用。我们的研究结果表明，TSG可以显著增强抗氧化活性，减轻d -半乳糖引起的肝损伤。代谢组学分析显示，衰老大鼠血清中3-羟基丁酸盐、琥珀酸盐和色氨酸水平升高，丙氨酸、精氨酸和醋酸盐水平降低。TSG治疗有效地逆转了这些代谢紊乱。进一步的通路分析表明，TSG恢复了苯丙氨酸和酪氨酸代谢、甜菜碱代谢、肉碱合成和蛋氨酸代谢等几个关键代谢通路的平衡。综上所述，TSG不仅增强了衰老大鼠的抗氧化防御能力，减轻了肝损伤，而且使代谢失调正常化。这些发现突出了TSG作为一种有前景的抗衰老药物的潜力，并支持其进一步探索临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

NMR-based metabolomics unveils the potential mechanism of tetrahydroxy stilbene glycoside in combating D-galactose-induced aging in rats

Aging represents a significant threat to human health, underscoring the critical need for effective anti-aging interventions. In this study, we utilized a comprehensive approach combining ¹H NMR-based metabolomics, serum biochemical analysis, and liver histopathology to evaluate the protective effects of tetrahydroxy stilbene glycoside (TSG) on D-galactose-induced aging in rats. Our findings demonstrate that TSG significantly enhances antioxidant activity and alleviates D-galactose-induced liver damage. Metabolomic analysis revealed increased levels in 3-hydroxybutyrate, succinate, and tryptophan, alongside decreased levels in alanine, arginine, and acetate, in the serum of aging rats. TSG treatment effectively reversed these metabolic perturbations. Further pathway analysis indicated that TSG restored balance in several key metabolic pathways, such as phenylalanine and tyrosine metabolism, betaine metabolism, carnitine synthesis, and methionine metabolism. In summary, TSG not only bolstered antioxidant defenses and alleviated liver injury but also normalized metabolic dysregulation in aging rats. These findings highlight TSG's potential as a promising anti-aging agent and support its further exploration for clinical applications.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.