核壳纳米致动器不同表面功能化对磁电驱动细胞生长的影响

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-03-31 DOI:10.1021/acsami.4c21337

Polina V. Chernozem, Alexander V. Romashchenko, Olga I. Solovieva, Azhar Zh. Ibraeva, Georgy Nosov, Danila A. Koptsev, Sergey A. Lisitsyn, Maria A. Surmeneva, Dmitry V. Wagner, Evgeny Yu. Gerasimov, Sergey O. Kazantsev, Aleksandr S. Lozhkomoev, Gleb B. Sukhorukov, Roman A. Surmenev, Roman V. Chernozem

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引用次数: 0

摘要

磁电（ME）纳米粒子（NPs）表现出磁性和电性能之间的强耦合，使通过电磁刺激无线控制生物过程成为可能，这为多种生物医学应用铺平了道路。然而，ME NPs的表面功能化及其对其结构、物理性质和生物反应的影响在很大程度上仍未被探索。在这项研究中，利用生物相容性柠檬酸（CA）和果胶（PEC）对由磁性尖晶石MnFe2O4核（~ 23 nm）和铁电钙钛矿Ba0.85Ca0.15Zr0.1Ti0.9O3 （BCZT）壳（~ 5 nm）组成的准球形ME核-壳NPs进行了功能化，并采用微波辅助水热法合成。表面功能化导致NPs的CA与金属离子通过螯合形成共价键。与CA（25.3±1.0 mV）相比，PEC的表面功能化使ME NPs的ζ电位值增加至- 46.2±0.6 mV。含有CA和PEC的MFO@BCZT NPs均具有较低的矫顽力值（分别为69±5和29±2 Oe）和明显的比饱和磁化强度（分别为6.1±0.2和5.2±0.2 emu/g）。与原始MFO岩心（754±23 Oe）相比，具有后续CA（746±22 Oe）和PEC（754±23 Oe）表面功能化的BCZT壳未观察到对ME NPs各向异性场的影响。CA-/ pec功能化的MFO@BCZT NPs具有稳定的压响应（分别为9.95±1.36和10.24±2.03 pm/V）和高ME响应（分别为81 × 104和80 × 104 mV·cm-1·e - 1），与最常研究的co基类似物相当。体外实验表明，开发的ME NPs能够控制钙通量，从而实现细胞增殖的双向调节。这项工作促进了高效和生物相容性的ME NPs的发展，在无创和靶向刺激细胞行为方面具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Effect of Various Surface Functionalizations of Core–Shell Nanoactuators on Magnetoelectrically Driven Cell Growth

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The Effect of Various Surface Functionalizations of Core–Shell Nanoactuators on Magnetoelectrically Driven Cell Growth

Magnetoelectric (ME) nanoparticles (NPs) exhibit strong coupling between magnetic and electric properties, enabling wireless control of biological processes through electromagnetic stimulation, which paves the way for diverse biomedical applications. However, the surface functionalization of ME NPs and its impact on their structure, physical properties, and biological response remain largely unexplored. In this study, biocompatible citric acid (CA) and pectin (PEC) were employed to functionalize quasi-spherical ME core–shell NPs comprising a magnetic spinel MnFe₂O₄ core (∼23 nm) and a ferroelectric perovskite Ba_0.85Ca_0.15Zr_0.1Ti_0.9O₃ (BCZT) shell (∼5 nm), synthesized using microwave-assisted hydrothermal processing. The surface functionalization led to the formation of covalent bonds between CA and metal ions of NPs via chelation. The surface functionalization with PEC increased ζ-potential values of ME NPs up to −46.2 ± 0.6 mV compared to CA (25.3 ± 1.0 mV). Both MFO@BCZT NPs with CA and PEC exhibited low coercivity values (69 ± 5 and 29 ± 2 Oe, respectively) with a pronounced specific saturation magnetization (6.1 ± 0.2 and 5.2 ± 0.2 emu/g, respectively). No effect of the BCZT shell with subsequent CA (746 ± 22 Oe) and PEC (754 ± 23 Oe) surface functionalizations on the anisotropy field of ME NPs was observed compared to the pristine MFO cores (754 ± 23 Oe). Both CA-/PEC-functionalized MFO@BCZT NPs exhibited ferroelectric behavior with robust piezoresponse (9.95 ± 1.36 and 10.24 ± 2.03 pm/V, respectively) and high ME response (81 × 10⁴ and 80 × 10⁴ mV·cm^–1·Oe^–1, respectively), comparable to the most frequently studied Co-based analogs. In vitro assays demonstrated the ability of the developed ME NPs to control calcium flux, which enables bidirectional regulation of cell proliferation. This work advances the development of efficient and biocompatible ME NPs with promising applications in the noninvasive and targeted stimulation of cell behavior.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.