Algorithm in chemistry: molecular logic gate-based data protection

Data security is crucial for safeguarding the integrity, authenticity, and confidentiality of documents, currency, merchant labels, and other paper-based assets, which sequentially has a profound impact on personal privacy and even national security. High-security-level logic data protection paradigms are typically limited to software (digital circuits) and rarely applied to physical devices using stimuli-responsive materials (SRMs). The main reason is that most SRMs lack programmable and controllable switching behaviors. Traditional SRMs usually produce static, singular, and highly predictable signals in response to stimuli, restricting them to simple “BUFFER” or “INVERT” logic operations with a low security level. However, recent advancements in SRMs have collectively enabled dynamic, multidimensional, and less predictable output signals under external stimuli. This breakthrough paves the way for sophisticated encryption and anti-counterfeiting hardware based on SRMs with complicated logic operations and algorithms. This review focuses on SRM-based data protection, emphasizing the integration of intricate logic and algorithms in SRM-constructed hardware, rather than chemical or material structural evolutions. It also discusses current challenges and explores the future directions of the field—such as combining SRMs with artificial intelligence (AI). This review fills a gap in the existing literature and represents a pioneering step into the uncharted territory of SRM-based encryption and anti-counterfeiting technologies.