{"title":"ABCB6多态性和血清水平与抗结核药物肝毒性易感性的关系","authors":"Ruina Chen, Jingru Cheng, Hongqiu Pan, Lihuan Lu, Xiaomin He, Meiling Zhang, Honggang Yi, Shaowen Tang","doi":"10.15403/jgld-5892","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aims: </strong>The occurrence of anti-tuberculosis drug-induced hepatotoxicity (ATDH) deserves our attention. To explore the role of ATP-binding cassette B6 (ABCB6) polymorphisms and serum levels in the risk of antituberculosis drug-induced hepatotoxicity (ATDH).</p><p><strong>Methods: </strong>A 1:4 matched case‒control study was conducted. Four single nucleotide polymorphisms (SNPs) and serum ABCB6 levels were analyzed, and false discovery rate (FDR) was performed to correct for multiple comparison.</p><p><strong>Results: </strong>224 ATDH cases and 896 controls were included. SNP rs1109867 in ABCB6 gene had a decreased risk of ATDH under dominant models (FDR corrected p-value = 0.027). Furthermore, serum ABCB6 levels at three different times in the ATDH cases were higher than those in the controls.</p><p><strong>Conclusions: </strong>SNP rs1109867 in ABCB6 gene may contribute to the susceptibility to ATDH among patients receiving anti-TB treatment.</p>","PeriodicalId":94081,"journal":{"name":"Journal of gastrointestinal and liver diseases : JGLD","volume":"34 1","pages":"55-63"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity.\",\"authors\":\"Ruina Chen, Jingru Cheng, Hongqiu Pan, Lihuan Lu, Xiaomin He, Meiling Zhang, Honggang Yi, Shaowen Tang\",\"doi\":\"10.15403/jgld-5892\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and aims: </strong>The occurrence of anti-tuberculosis drug-induced hepatotoxicity (ATDH) deserves our attention. To explore the role of ATP-binding cassette B6 (ABCB6) polymorphisms and serum levels in the risk of antituberculosis drug-induced hepatotoxicity (ATDH).</p><p><strong>Methods: </strong>A 1:4 matched case‒control study was conducted. Four single nucleotide polymorphisms (SNPs) and serum ABCB6 levels were analyzed, and false discovery rate (FDR) was performed to correct for multiple comparison.</p><p><strong>Results: </strong>224 ATDH cases and 896 controls were included. SNP rs1109867 in ABCB6 gene had a decreased risk of ATDH under dominant models (FDR corrected p-value = 0.027). Furthermore, serum ABCB6 levels at three different times in the ATDH cases were higher than those in the controls.</p><p><strong>Conclusions: </strong>SNP rs1109867 in ABCB6 gene may contribute to the susceptibility to ATDH among patients receiving anti-TB treatment.</p>\",\"PeriodicalId\":94081,\"journal\":{\"name\":\"Journal of gastrointestinal and liver diseases : JGLD\",\"volume\":\"34 1\",\"pages\":\"55-63\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of gastrointestinal and liver diseases : JGLD\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15403/jgld-5892\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of gastrointestinal and liver diseases : JGLD","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15403/jgld-5892","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association of ABCB6 Polymorphisms and Serum Levels with Susceptibility to Antituberculosis Drug-induced Hepatotoxicity.
Background and aims: The occurrence of anti-tuberculosis drug-induced hepatotoxicity (ATDH) deserves our attention. To explore the role of ATP-binding cassette B6 (ABCB6) polymorphisms and serum levels in the risk of antituberculosis drug-induced hepatotoxicity (ATDH).
Methods: A 1:4 matched case‒control study was conducted. Four single nucleotide polymorphisms (SNPs) and serum ABCB6 levels were analyzed, and false discovery rate (FDR) was performed to correct for multiple comparison.
Results: 224 ATDH cases and 896 controls were included. SNP rs1109867 in ABCB6 gene had a decreased risk of ATDH under dominant models (FDR corrected p-value = 0.027). Furthermore, serum ABCB6 levels at three different times in the ATDH cases were higher than those in the controls.
Conclusions: SNP rs1109867 in ABCB6 gene may contribute to the susceptibility to ATDH among patients receiving anti-TB treatment.
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