刺激参数招募不同的皮质-皮质通路:从tms诱发电位的微观状态分析的见解。

IF 2.3 3区 医学 Q3 CLINICAL NEUROLOGY
Delia Lucarelli, Giacomo Guidali, Dominika Sulcova, Agnese Zazio, Natale Salvatore Bonfiglio, Antonietta Stango, Guido Barchiesi, Marta Bortoletto
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引用次数: 0

摘要

经颅磁刺激(TMS)诱发电位(TEPs)是一种检测大脑连通性和开发精神疾病生物标志物的创新方法。因此,最小化研究和参与者之间的TEP差异(可能源于方法选择)是至关重要的。通过经典峰分析和微观状态研究相结合,我们测试了针对初级运动皮层(M1)的TMS脉冲波形和电流方向如何影响皮质-皮质回路的结合。我们的目标是弄清楚改变这些参数是否会影响相同神经回路的激活程度,或者是否会导致诱导激活传播的途径发生变化。采用TMS-EEG对32名健康受试者进行脉冲波形(单相、双相)和电流方向(后-前、前-后、后-内)控制实验。我们评估了M1-TEP组分的潜伏期和振幅,并采用微观状态分析来测试地形的差异。结果表明,TMS参数对M1-TEP组分振幅的影响较大,但对其潜伏期的影响较小。微态分析表明,单相刺激的电流方向改变了TEP早期潜伏期诱发的微态模式,以及它们的持续时间和全局电场功率。本研究表明,单相脉冲的电流方向可能会更有选择性地调节TEP信号的皮质源,激活神经群和皮质-皮质通路。双相刺激减少了与电流方向相关的变异性,可能更适合于颅磁刺激对解剖信息不透明的情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stimulation Parameters Recruit Distinct Cortico-Cortical Pathways: Insights from Microstate Analysis on TMS-Evoked Potentials.

Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) represent an innovative measure for examining brain connectivity and developing biomarkers of psychiatric conditions. Minimizing TEP variability across studies and participants, which may stem from methodological choices, is therefore vital. By combining classic peak analysis and microstate investigation, we tested how TMS pulse waveform and current direction may affect cortico-cortical circuit engagement when targeting the primary motor cortex (M1). We aim to disentangle whether changing these parameters affects the degree of activation of the same neural circuitry or may lead to changes in the pathways through which the induced activation spreads. Thirty-two healthy participants underwent a TMS-EEG experiment in which the pulse waveform (monophasic, biphasic) and current direction (posterior-anterior, anterior-posterior, latero-medial) were manipulated. We assessed the latency and amplitude of M1-TEP components and employed microstate analyses to test differences in topographies. Results revealed that TMS parameters strongly influenced M1-TEP components' amplitude but had a weaker role over their latencies. Microstate analysis showed that the current direction in monophasic stimulations changed the pattern of evoked microstates at the early TEP latencies, as well as their duration and global field power. This study shows that the current direction of monophasic pulses may modulate cortical sources contributing to TEP signals, activating neural populations and cortico-cortical paths more selectively. Biphasic stimulation reduces the variability associated with current direction and may be better suited when TMS targeting is blind to anatomical information.

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来源期刊
Brain Topography
Brain Topography 医学-临床神经学
CiteScore
4.70
自引率
7.40%
发文量
41
审稿时长
3 months
期刊介绍: Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.
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