IF 4 2区 生物学 Q1 GENETICS & HEREDITY
Atsushi Shibai, Minako Izutsu, Hazuki Kotani, Chikara Furusawa
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引用次数: 0

摘要

变异是生物进化的最终源泉,它在种群中产生遗传变异。变异可以创造新的优势性状,但也可能干扰生物体原有的功能。因此,生物可能已将突变率进化到适当的水平,以维持或提高其适应性。在本研究中,我们旨在通过实验量化突变率与抗生素耐药性进化之间的关系。我们使用 12 株突变率增加的大肠杆菌突变株和 5 种抗生素进行了进化实验。结果表明,除了突变率最高的一株突变菌株的进化速度明显下降之外,其他菌株的适应速度普遍随着突变率的提高而提高。为了进一步阐明这些发现,我们建立了一个简单的种群动力学模型,该模型成功地再现了所观察到的适应速度对突变率的依赖关系。这些发现为突变率的进化提供了重要的启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quantitative analysis of relationship between mutation rate and speed of adaptation under antibiotic exposure in Escherichia coli.

Mutations are the ultimate source of biological evolution that creates genetic variation in populations. Mutations can create new advantageous traits but can also potentially interfere with pre-existing organismal functions. Therefore, organisms may have evolved mutation rates to appropriate levels to maintain or improve their fitness. In this study, we aimed to experimentally quantify the relationship between the mutation rate and evolution of antibiotic resistance. We conducted an evolution experiment using 12 Escherichia coli mutator strains with increased mutation rates and five antibiotics. Our results demonstrated that the rate of adaptation generally increased with higher mutation rates, except in a single mutator strain with the highest mutation rate, which exhibited a significant decline in evolutionary speed. To further elucidate these findings, we developed a simple population dynamics model that successfully recapitulated the observed dependence of adaptation speed on mutation rate. These findings provide important insights into the evolution of mutation rate accompanied by the evolution.

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来源期刊
PLoS Genetics
PLoS Genetics GENETICS & HEREDITY-
自引率
2.20%
发文量
438
期刊介绍: PLOS Genetics is run by an international Editorial Board, headed by the Editors-in-Chief, Greg Barsh (HudsonAlpha Institute of Biotechnology, and Stanford University School of Medicine) and Greg Copenhaver (The University of North Carolina at Chapel Hill). Articles published in PLOS Genetics are archived in PubMed Central and cited in PubMed.
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